Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells

The PDL1-PD1 immune checkpoint inhibits T cell activation, and its blockade is effective in a subset of patients. Studies are investigating how checkpoints are hijacked by cancer cells and why most patients remain resistant to immunotherapy. Epithelial mesenchymal transition (EMT), which drives tumo...

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Detalles Bibliográficos
Autores principales: Guo, Yan, Lu, Xiaoqin, Chen, Yao, Rendon, Beatriz, Mitchell, Robert A., Cuatrecasas, Miriam, Cortés, Marlies, Postigo, Antonio, Liu, Yongqing, Dean, Douglas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139582/
https://www.ncbi.nlm.nih.gov/pubmed/34020945
http://dx.doi.org/10.1126/sciadv.abd7455

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