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A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited numb...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139589/ https://www.ncbi.nlm.nih.gov/pubmed/34020961 http://dx.doi.org/10.1126/sciadv.abg9614 |
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author | Gao, Yuji Nguyen, Dat T. Yeo, Trifanny Lim, Su Bin Tan, Wei Xian Madden, Leigh Edward Jin, Lin Long, Ji Yong Kenan Aloweni, Fazila Abu Bakar Liew, Yi Jia Angela Tan, Mandy Li Ling Ang, Shin Yuh Maniya, Sivagame D/O Abdelwahab, Ibrahim Loh, Kian Ping Chen, Chia-Hung Becker, David Laurence Leavesley, David Ho, John S. Lim, Chwee Teck |
author_facet | Gao, Yuji Nguyen, Dat T. Yeo, Trifanny Lim, Su Bin Tan, Wei Xian Madden, Leigh Edward Jin, Lin Long, Ji Yong Kenan Aloweni, Fazila Abu Bakar Liew, Yi Jia Angela Tan, Mandy Li Ling Ang, Shin Yuh Maniya, Sivagame D/O Abdelwahab, Ibrahim Loh, Kian Ping Chen, Chia-Hung Becker, David Laurence Leavesley, David Ho, John S. Lim, Chwee Teck |
author_sort | Gao, Yuji |
collection | PubMed |
description | Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor–α, interleukin-6 (IL-6), IL-8, and transforming growth factor–β1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes. |
format | Online Article Text |
id | pubmed-8139589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81395892021-05-26 A flexible multiplexed immunosensor for point-of-care in situ wound monitoring Gao, Yuji Nguyen, Dat T. Yeo, Trifanny Lim, Su Bin Tan, Wei Xian Madden, Leigh Edward Jin, Lin Long, Ji Yong Kenan Aloweni, Fazila Abu Bakar Liew, Yi Jia Angela Tan, Mandy Li Ling Ang, Shin Yuh Maniya, Sivagame D/O Abdelwahab, Ibrahim Loh, Kian Ping Chen, Chia-Hung Becker, David Laurence Leavesley, David Ho, John S. Lim, Chwee Teck Sci Adv Research Articles Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor–α, interleukin-6 (IL-6), IL-8, and transforming growth factor–β1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes. American Association for the Advancement of Science 2021-05-21 /pmc/articles/PMC8139589/ /pubmed/34020961 http://dx.doi.org/10.1126/sciadv.abg9614 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Gao, Yuji Nguyen, Dat T. Yeo, Trifanny Lim, Su Bin Tan, Wei Xian Madden, Leigh Edward Jin, Lin Long, Ji Yong Kenan Aloweni, Fazila Abu Bakar Liew, Yi Jia Angela Tan, Mandy Li Ling Ang, Shin Yuh Maniya, Sivagame D/O Abdelwahab, Ibrahim Loh, Kian Ping Chen, Chia-Hung Becker, David Laurence Leavesley, David Ho, John S. Lim, Chwee Teck A flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
title | A flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
title_full | A flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
title_fullStr | A flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
title_full_unstemmed | A flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
title_short | A flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
title_sort | flexible multiplexed immunosensor for point-of-care in situ wound monitoring |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139589/ https://www.ncbi.nlm.nih.gov/pubmed/34020961 http://dx.doi.org/10.1126/sciadv.abg9614 |
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