Cargando…

Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats

Research into the neural mechanisms that underlie higher-order cognitive control of eating behavior suggests that ventral hippocampal (vHC) neurons, which are critical for emotional memory, also inhibit energy intake. We showed previously that optogenetically inhibiting vHC glutamatergic neurons dur...

Descripción completa

Detalles Bibliográficos
Autores principales: Briggs, Sherri B., Hannapel, Reilly, Ramesh, Janavi, Parent, Marise B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139633/
https://www.ncbi.nlm.nih.gov/pubmed/34011515
http://dx.doi.org/10.1101/lm.053215.120
_version_ 1783696046716616704
author Briggs, Sherri B.
Hannapel, Reilly
Ramesh, Janavi
Parent, Marise B.
author_facet Briggs, Sherri B.
Hannapel, Reilly
Ramesh, Janavi
Parent, Marise B.
author_sort Briggs, Sherri B.
collection PubMed
description Research into the neural mechanisms that underlie higher-order cognitive control of eating behavior suggests that ventral hippocampal (vHC) neurons, which are critical for emotional memory, also inhibit energy intake. We showed previously that optogenetically inhibiting vHC glutamatergic neurons during the early postprandial period, when the memory of the meal would be undergoing consolidation, caused rats to eat their next meal sooner and to eat more during that next meal when the neurons were no longer inhibited. The present research determined whether manipulations known to interfere with synaptic plasticity and memory when given pretraining would increase energy intake when given prior to ingestion. Specifically, we tested the effects of blocking vHC glutamatergic N-methyl-D-aspartate receptors (NMDARs) and activity-regulated cytoskeleton-associated protein (Arc) on sucrose ingestion. The results showed that male rats consumed a larger sucrose meal on days when they were given vHC infusions of the NMDAR antagonist APV or Arc antisense oligodeoxynucleotides than on days when they were given control infusions. The rats did not accommodate for that increase by delaying the onset of their next sucrose meal (i.e., decreased satiety ratio) or by eating less during the next meal. These data suggest that vHC NMDARs and Arc limit meal size and inhibit meal initiation.
format Online
Article
Text
id pubmed-8139633
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-81396332022-06-01 Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats Briggs, Sherri B. Hannapel, Reilly Ramesh, Janavi Parent, Marise B. Learn Mem Research Research into the neural mechanisms that underlie higher-order cognitive control of eating behavior suggests that ventral hippocampal (vHC) neurons, which are critical for emotional memory, also inhibit energy intake. We showed previously that optogenetically inhibiting vHC glutamatergic neurons during the early postprandial period, when the memory of the meal would be undergoing consolidation, caused rats to eat their next meal sooner and to eat more during that next meal when the neurons were no longer inhibited. The present research determined whether manipulations known to interfere with synaptic plasticity and memory when given pretraining would increase energy intake when given prior to ingestion. Specifically, we tested the effects of blocking vHC glutamatergic N-methyl-D-aspartate receptors (NMDARs) and activity-regulated cytoskeleton-associated protein (Arc) on sucrose ingestion. The results showed that male rats consumed a larger sucrose meal on days when they were given vHC infusions of the NMDAR antagonist APV or Arc antisense oligodeoxynucleotides than on days when they were given control infusions. The rats did not accommodate for that increase by delaying the onset of their next sucrose meal (i.e., decreased satiety ratio) or by eating less during the next meal. These data suggest that vHC NMDARs and Arc limit meal size and inhibit meal initiation. Cold Spring Harbor Laboratory Press 2021-06 /pmc/articles/PMC8139633/ /pubmed/34011515 http://dx.doi.org/10.1101/lm.053215.120 Text en © 2021 Briggs et al.; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
Briggs, Sherri B.
Hannapel, Reilly
Ramesh, Janavi
Parent, Marise B.
Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats
title Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats
title_full Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats
title_fullStr Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats
title_full_unstemmed Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats
title_short Inhibiting ventral hippocampal NMDA receptors and Arc increases energy intake in male rats
title_sort inhibiting ventral hippocampal nmda receptors and arc increases energy intake in male rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139633/
https://www.ncbi.nlm.nih.gov/pubmed/34011515
http://dx.doi.org/10.1101/lm.053215.120
work_keys_str_mv AT briggssherrib inhibitingventralhippocampalnmdareceptorsandarcincreasesenergyintakeinmalerats
AT hannapelreilly inhibitingventralhippocampalnmdareceptorsandarcincreasesenergyintakeinmalerats
AT rameshjanavi inhibitingventralhippocampalnmdareceptorsandarcincreasesenergyintakeinmalerats
AT parentmariseb inhibitingventralhippocampalnmdareceptorsandarcincreasesenergyintakeinmalerats