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Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells

In many enveloped virus families, including human immunodeficiency virus (HIV) and herpes simplex virus (HSV), a crucial, yet unexploited, step in the viral life cycle is the release of particles from the infected cell membranes. This release process is mediated by host ESCRT complex proteins, which...

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Detalles Bibliográficos
Autores principales: Leis, Jonathan, Luan, Chi-Hao, Audia, James E., Dunne, Sara F., Heath, Carissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139698/
https://www.ncbi.nlm.nih.gov/pubmed/33731460
http://dx.doi.org/10.1128/JVI.00190-21