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Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays

Pseudotyped viruses are valuable tools for studying virulent or lethal viral pathogens that need to be handled in biosafety level 3 (BSL3) or higher facilities. With the explosive spread of the coronavirus disease 2019 (COVID-19) pandemic, the establishment of a BSL2 adapted severe acute respiratory...

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Detalles Bibliográficos
Autores principales: Yu, Jingyou, Li, Zhenfeng, He, Xuan, Gebre, Makda S., Bondzie, Esther A., Wan, Huahua, Jacob-Dolan, Catherine, Martinez, David R., Nkolola, Joseph P., Baric, Ralph S., Barouch, Dan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139703/
https://www.ncbi.nlm.nih.gov/pubmed/33727331
http://dx.doi.org/10.1128/JVI.00044-21