Cargando…

Diabetes Mellitus Promotes Atrial Structural Remodeling and PARP-1/Ikkα/NF-κB Pathway Activation in Mice

BACKGROUND: Diabetes mellitus (DM) has been demonstrated to be linked to atrial fibrillation (AF). However, the underlying mechanisms of the DM-associated increase in AF susceptibility and the potential effects of DM on atrial remodeling remain unclear. METHODS AND RESULTS: Twenty-five C57BL/6 mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Tianyu, Wang, Jie, Tang, Manyun, Liu, Shangyu, Ding, Ligang, Yan, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139946/ https://www.ncbi.nlm.nih.gov/pubmed/34040405 http://dx.doi.org/10.2147/DMSO.S300616

Ejemplares similares

Attribution of NF-κB Activity to CHUK/IKKα-Involved Carcinogenesis
por: Li, Xin, et al.
Publicado: (2021)

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway
por: Adli, Mazhar, et al.
Publicado: (2010)

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
por: Shukla, Sanjeev, et al.
Publicado: (2015)

Inhibition of Osteoblast Functions by IKK/NF-κB in Osteoporosis
por: Chang, Jia, et al.
Publicado: (2009)

IKKβ/NF-κB and the miscreant macrophage
por: Timmer, Anjuli M., et al.
Publicado: (2008)

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling
por: Kenneth, Niall S., et al.
Publicado: (2012)

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation
por: Olivotto, Eleonora, et al.
Publicado: (2015)

IKKα plays a major role in canonical NF-κB signalling in colorectal cells
por: Prescott, Jack A., et al.
Publicado: (2022)

A computational model of the DNA damage-induced IKK/ NF-κB pathway reveals a critical dependence on irradiation dose and PARP-1
por: Konrath, Fabian, et al.
Publicado: (2023)

IKKα Contributes to Canonical NF-κB Activation Downstream of Nod1-Mediated Peptidoglycan Recognition
por: Kim, Man Lyang, et al.
Publicado: (2010)

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism
por: Bakkar, Nadine, et al.
Publicado: (2012)

Her2 Activates NF-κB and Induces Invasion Through the Canonical Pathway Involving IKKα
por: Merkhofer, Evan C, et al.
Publicado: (2009)

VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer
por: Chen, Jionghuang, et al.
Publicado: (2022)

Brevilin A Ameliorates Acute Lung Injury and Inflammation Through Inhibition of NF-κB Signaling via Targeting IKKα/β
por: Liu, Lu, et al.
Publicado: (2022)

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer
por: Nottingham, Liesl K., et al.
Publicado: (2013)

Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases
por: Olivotto, Eleonora, et al.
Publicado: (2021)

Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis
por: Wagner, Vivian P., et al.
Publicado: (2016)

Crosstalk between the NF-κB activating IKK-complex and the CSN signalosome
por: Orel, Lukas, et al.
Publicado: (2010)

Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster
por: Bandarra, Daniel, et al.
Publicado: (2014)

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance
por: Rinkenbaugh, Amanda L., et al.
Publicado: (2016)

NF‐κB/IKK activation by small extracellular vesicles within the SASP
por: Fafián‐Labora, Juan Antonio, et al.
Publicado: (2021)

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
por: Charalambous, M P, et al.
Publicado: (2009)

Regional Susceptibility to TNF-α Induction of Murine Brain Inflammation via Classical IKK/NF-κB Signalling
por: Young, Adam M. H., et al.
Publicado: (2012)

MicroRNAs modulate the noncanonical NF-κB pathway by regulating IKKα expression during macrophage differentiation
por: Li, Tao, et al.
Publicado: (2010)

Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH
por: Zhang, Guo, et al.
Publicado: (2013)

Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
por: Paul, Andrew, et al.
Publicado: (2018)

Role of cantharidin in the activation of IKKα/IκBα/NF-κB pathway by inhibiting PP2A activity in cholangiocarcinoma cell lines
por: Zhou, Huijiang, et al.
Publicado: (2018)

Uncoupling Obesity-related Hypertension by Targeting Hypothalamic IKKβ/NF-κB
por: Purkayastha, Sudarshana, et al.
Publicado: (2011)

Constitutive Activation of IKK2/NF-κB Impairs Osteogenesis and Skeletal Development
por: Swarnkar, Gaurav, et al.
Publicado: (2014)

PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase
por: Agarwal, Nitin Kumar, et al.
Publicado: (2014)

Tumor necrosis factor α triggers proliferation of adult neural stem cells via IKK/NF-κB signaling
por: Widera, Darius, et al.
Publicado: (2006)

IKKε Knockout Prevents High Fat Diet Induced Arterial Atherosclerosis and NF-κB Signaling in Mice
por: Cao, Changchun, et al.
Publicado: (2013)

Pparα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes
por: Wei, Ping, et al.
Publicado: (2023)

The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging
por: Choi, Yeon Ja, et al.
Publicado: (2016)

ETS1 is associated with cisplatin resistance through IKKα/NF-κB pathway in cell line MDA-MB-231
por: Zhang, Yuzhu, et al.
Publicado: (2018)

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2012)

Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
por: Yang, Cheng-Hao, et al.
Publicado: (2012)

Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren's Syndrome Immunopathogenesis
por: Chen, Weiqian, et al.
Publicado: (2015)

IKK2/NF-κB signaling protects neurons after traumatic brain injury
por: Mettang, Melanie, et al.
Publicado: (2018)

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
por: Fusella, Federica, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eudm5b63uopa2iblgt86vu5l2k