Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis are regulated in lens cells remains unclear. Here, we show that Quaking (Qki) is required for the transcriptional activation of genes involved in cholester...

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Detalles Bibliográficos
Autores principales: Shin, Seula, Zhou, Hao, He, Chenxi, Wei, Yanjun, Wang, Yunfei, Shingu, Takashi, Zeng, Ailiang, Wang, Shaobo, Zhou, Xin, Li, Hongtao, Zhang, Qiang, Mo, Qinling, Long, Jiafu, Lan, Fei, Chen, Yiwen, Hu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139980/
https://www.ncbi.nlm.nih.gov/pubmed/34021134
http://dx.doi.org/10.1038/s41467-021-22782-0

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