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Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature
Penile cancer is a rare condition, which mostly affects men in their sixth decade of life. The most common histology is squamous cell carcinoma (SCC), with about half of the cases linked to human papilloma virus (HPV) infection. The lack of awareness and significant social and psychological stigma a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140030/ https://www.ncbi.nlm.nih.gov/pubmed/33454930 http://dx.doi.org/10.1007/s40487-020-00135-z |
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author | Stecca, Carlos E. Alt, Marie Jiang, Di Maria Chung, Peter Crook, Juanita M. Kulkarni, Girish S. Sridhar, Srikala S. |
author_facet | Stecca, Carlos E. Alt, Marie Jiang, Di Maria Chung, Peter Crook, Juanita M. Kulkarni, Girish S. Sridhar, Srikala S. |
author_sort | Stecca, Carlos E. |
collection | PubMed |
description | Penile cancer is a rare condition, which mostly affects men in their sixth decade of life. The most common histology is squamous cell carcinoma (SCC), with about half of the cases linked to human papilloma virus (HPV) infection. The lack of awareness and significant social and psychological stigma associated with penile cancer often leads to delays in presentation, diagnosis and management. Timely multidisciplinary care at experienced centers is therefore critical for improving outcomes. For patients with advanced disease, treatment options are limited and prognosis remains poor. Large international efforts are underway to further define the optimal standards of care. Targeted therapies and immune checkpoint inhibitors could potentially play a role in advanced disease and are under evaluation in clinical trials. In this review, we discuss the current management of penile cancer and future directions. |
format | Online Article Text |
id | pubmed-8140030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-81400302021-06-03 Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature Stecca, Carlos E. Alt, Marie Jiang, Di Maria Chung, Peter Crook, Juanita M. Kulkarni, Girish S. Sridhar, Srikala S. Oncol Ther Review Penile cancer is a rare condition, which mostly affects men in their sixth decade of life. The most common histology is squamous cell carcinoma (SCC), with about half of the cases linked to human papilloma virus (HPV) infection. The lack of awareness and significant social and psychological stigma associated with penile cancer often leads to delays in presentation, diagnosis and management. Timely multidisciplinary care at experienced centers is therefore critical for improving outcomes. For patients with advanced disease, treatment options are limited and prognosis remains poor. Large international efforts are underway to further define the optimal standards of care. Targeted therapies and immune checkpoint inhibitors could potentially play a role in advanced disease and are under evaluation in clinical trials. In this review, we discuss the current management of penile cancer and future directions. Springer Healthcare 2021-01-16 /pmc/articles/PMC8140030/ /pubmed/33454930 http://dx.doi.org/10.1007/s40487-020-00135-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Stecca, Carlos E. Alt, Marie Jiang, Di Maria Chung, Peter Crook, Juanita M. Kulkarni, Girish S. Sridhar, Srikala S. Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature |
title | Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature |
title_full | Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature |
title_fullStr | Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature |
title_full_unstemmed | Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature |
title_short | Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature |
title_sort | recent advances in the management of penile cancer: a contemporary review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140030/ https://www.ncbi.nlm.nih.gov/pubmed/33454930 http://dx.doi.org/10.1007/s40487-020-00135-z |
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