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UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer

UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 in oxaliplatin resistance in colorectal cancer (CRC) remains unknown. In our study, UPF1 is upregulated in CRC in mRNA and protein levels and overexpression of UPF1 predicts a poor overall surviv...

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Detalles Bibliográficos
Autores principales:	Zhu, Congcong, Zhang, Long, Zhao, Senlin, Dai, Weixing, Xu, Yun, Zhang, Yuqin, Zheng, Hongtu, Sheng, Weiqi, Xu, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140095/ https://www.ncbi.nlm.nih.gov/pubmed/34021129 http://dx.doi.org/10.1038/s41419-021-03798-2

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