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Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets
Understanding the structural determinants of a protein’s biochemical properties, such as activity and stability, is a major challenge in biology and medicine. Comparing computer simulations of protein variants with different biochemical properties is an increasingly powerful means to drive progress....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140102/ https://www.ncbi.nlm.nih.gov/pubmed/34021153 http://dx.doi.org/10.1038/s41467-021-23246-1 |