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Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival

The immunosuppressive regimen for clinical allogeneic islet transplantation uses beta cell–toxic compounds such as tacrolimus that cause islet graft loss. Previously we reported that the plant-derived steroidal lactone Withaferin A (WA) can protect islet grafts by inhibiting nuclear factor-kappa B (...

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Detalles Bibliográficos
Autores principales:	Kumano, Kenjiro, Kanak, Mazhar A., Saravanan, Prathab Balaji, Blanck, J. P., Liu, Yang, Vasu, Srividya, Lawrence, Michael, Naziruddin, Bashoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140140/ https://www.ncbi.nlm.nih.gov/pubmed/34021233 http://dx.doi.org/10.1038/s41598-021-90181-y

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