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HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study
INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia‐Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS‐defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140190/ https://www.ncbi.nlm.nih.gov/pubmed/34021711 http://dx.doi.org/10.1002/jia2.25736 |
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author | Han, Win Min Jiamsakul, Awachana Salleh, Nur Afiqah Mohd Choi, Jun Yong Huy, Bui Vu Yunihastuti, Evy Do, Cuong Duy Merati, Tuti P Gani, Yasmin M Kiertiburanakul, Sasisopin Zhang, Fujie Chan, Yu‐Jiun Lee, Man‐Po Chaiwarith, Romanee Ng, Oon Tek Khusuwan, Suwimon Ditangco, Rossana Kumarasamy, Nagalingeswaran Sangle, Shashikala Ross, Jeremy Avihingsanon, Anchalee Khol, V Zhang, FJ Zhao, HX Han, N Lee, MP Li, PCK Lam, W Chan, YT Kumarasamy, N Ezhilarasi, C Pujari, S Joshi, K Gaikwad, S Chitalikar, A Sangle, S Mave, V Marbaniang, I Nimkar, S Merati, TP Wirawan, DN Yuliana, F Yunihastuti, E Widhani, A Maria, S Karjadi, TH Oka, S Nishijima, T Choi, JY Na, S Kim, JM Gani, YM Rudi, NB Azwa, I Kamarulzaman, A Syed Omar, SF Ponnampalavanar, S Ditangco, R Pasayan, MK Mationg, ML Chan, YJ Ku, WW Wu, PC Ke, E Ng, OT Lim, PL Lee, LS Liang, D Ng, OT Avihingsanon, A Gatechompol, S Phanuphak, P Phadungphon, C Kiertiburanakul, S Phuphuakrat, A Chumla, L Sanmeema, N Chaiwarith, R Sirisanthana, T Praparattanapan, J Nuket, K Khusuwan, S Kantipong, P Kambua, P Nguyen, KV Bui, HV Nguyen, DTH Nguyen, DT Do, CD Ngo, AV Nguyen, LT Sohn, AH Ross, JL Petersen, B Law, MG Jiamsakul, A Bijker, R Rupasinghe, D |
author_facet | Han, Win Min Jiamsakul, Awachana Salleh, Nur Afiqah Mohd Choi, Jun Yong Huy, Bui Vu Yunihastuti, Evy Do, Cuong Duy Merati, Tuti P Gani, Yasmin M Kiertiburanakul, Sasisopin Zhang, Fujie Chan, Yu‐Jiun Lee, Man‐Po Chaiwarith, Romanee Ng, Oon Tek Khusuwan, Suwimon Ditangco, Rossana Kumarasamy, Nagalingeswaran Sangle, Shashikala Ross, Jeremy Avihingsanon, Anchalee Khol, V Zhang, FJ Zhao, HX Han, N Lee, MP Li, PCK Lam, W Chan, YT Kumarasamy, N Ezhilarasi, C Pujari, S Joshi, K Gaikwad, S Chitalikar, A Sangle, S Mave, V Marbaniang, I Nimkar, S Merati, TP Wirawan, DN Yuliana, F Yunihastuti, E Widhani, A Maria, S Karjadi, TH Oka, S Nishijima, T Choi, JY Na, S Kim, JM Gani, YM Rudi, NB Azwa, I Kamarulzaman, A Syed Omar, SF Ponnampalavanar, S Ditangco, R Pasayan, MK Mationg, ML Chan, YJ Ku, WW Wu, PC Ke, E Ng, OT Lim, PL Lee, LS Liang, D Ng, OT Avihingsanon, A Gatechompol, S Phanuphak, P Phadungphon, C Kiertiburanakul, S Phuphuakrat, A Chumla, L Sanmeema, N Chaiwarith, R Sirisanthana, T Praparattanapan, J Nuket, K Khusuwan, S Kantipong, P Kambua, P Nguyen, KV Bui, HV Nguyen, DTH Nguyen, DT Do, CD Ngo, AV Nguyen, LT Sohn, AH Ross, JL Petersen, B Law, MG Jiamsakul, A Bijker, R Rupasinghe, D |
author_sort | Han, Win Min |
collection | PubMed |
description | INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia‐Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS‐defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia‐Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre‐ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year‐10 (n = 78). Higher follow‐up HIV viral load and pre‐ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2‐, 5‐ and 10‐years following ART initiation. There were 52 new AIDS‐defining events and 50 deaths during 3347 person‐years of follow‐up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS‐defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. |
format | Online Article Text |
id | pubmed-8140190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81401902021-05-26 HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study Han, Win Min Jiamsakul, Awachana Salleh, Nur Afiqah Mohd Choi, Jun Yong Huy, Bui Vu Yunihastuti, Evy Do, Cuong Duy Merati, Tuti P Gani, Yasmin M Kiertiburanakul, Sasisopin Zhang, Fujie Chan, Yu‐Jiun Lee, Man‐Po Chaiwarith, Romanee Ng, Oon Tek Khusuwan, Suwimon Ditangco, Rossana Kumarasamy, Nagalingeswaran Sangle, Shashikala Ross, Jeremy Avihingsanon, Anchalee Khol, V Zhang, FJ Zhao, HX Han, N Lee, MP Li, PCK Lam, W Chan, YT Kumarasamy, N Ezhilarasi, C Pujari, S Joshi, K Gaikwad, S Chitalikar, A Sangle, S Mave, V Marbaniang, I Nimkar, S Merati, TP Wirawan, DN Yuliana, F Yunihastuti, E Widhani, A Maria, S Karjadi, TH Oka, S Nishijima, T Choi, JY Na, S Kim, JM Gani, YM Rudi, NB Azwa, I Kamarulzaman, A Syed Omar, SF Ponnampalavanar, S Ditangco, R Pasayan, MK Mationg, ML Chan, YJ Ku, WW Wu, PC Ke, E Ng, OT Lim, PL Lee, LS Liang, D Ng, OT Avihingsanon, A Gatechompol, S Phanuphak, P Phadungphon, C Kiertiburanakul, S Phuphuakrat, A Chumla, L Sanmeema, N Chaiwarith, R Sirisanthana, T Praparattanapan, J Nuket, K Khusuwan, S Kantipong, P Kambua, P Nguyen, KV Bui, HV Nguyen, DTH Nguyen, DT Do, CD Ngo, AV Nguyen, LT Sohn, AH Ross, JL Petersen, B Law, MG Jiamsakul, A Bijker, R Rupasinghe, D J Int AIDS Soc Research Articles INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia‐Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS‐defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia‐Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre‐ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year‐10 (n = 78). Higher follow‐up HIV viral load and pre‐ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2‐, 5‐ and 10‐years following ART initiation. There were 52 new AIDS‐defining events and 50 deaths during 3347 person‐years of follow‐up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS‐defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. John Wiley and Sons Inc. 2021-05-21 /pmc/articles/PMC8140190/ /pubmed/34021711 http://dx.doi.org/10.1002/jia2.25736 Text en © 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Han, Win Min Jiamsakul, Awachana Salleh, Nur Afiqah Mohd Choi, Jun Yong Huy, Bui Vu Yunihastuti, Evy Do, Cuong Duy Merati, Tuti P Gani, Yasmin M Kiertiburanakul, Sasisopin Zhang, Fujie Chan, Yu‐Jiun Lee, Man‐Po Chaiwarith, Romanee Ng, Oon Tek Khusuwan, Suwimon Ditangco, Rossana Kumarasamy, Nagalingeswaran Sangle, Shashikala Ross, Jeremy Avihingsanon, Anchalee Khol, V Zhang, FJ Zhao, HX Han, N Lee, MP Li, PCK Lam, W Chan, YT Kumarasamy, N Ezhilarasi, C Pujari, S Joshi, K Gaikwad, S Chitalikar, A Sangle, S Mave, V Marbaniang, I Nimkar, S Merati, TP Wirawan, DN Yuliana, F Yunihastuti, E Widhani, A Maria, S Karjadi, TH Oka, S Nishijima, T Choi, JY Na, S Kim, JM Gani, YM Rudi, NB Azwa, I Kamarulzaman, A Syed Omar, SF Ponnampalavanar, S Ditangco, R Pasayan, MK Mationg, ML Chan, YJ Ku, WW Wu, PC Ke, E Ng, OT Lim, PL Lee, LS Liang, D Ng, OT Avihingsanon, A Gatechompol, S Phanuphak, P Phadungphon, C Kiertiburanakul, S Phuphuakrat, A Chumla, L Sanmeema, N Chaiwarith, R Sirisanthana, T Praparattanapan, J Nuket, K Khusuwan, S Kantipong, P Kambua, P Nguyen, KV Bui, HV Nguyen, DTH Nguyen, DT Do, CD Ngo, AV Nguyen, LT Sohn, AH Ross, JL Petersen, B Law, MG Jiamsakul, A Bijker, R Rupasinghe, D HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study |
title | HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study |
title_full | HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study |
title_fullStr | HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study |
title_full_unstemmed | HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study |
title_short | HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia‐Pacific region: a longitudinal cohort study |
title_sort | hiv treatment outcomes among people who acquired hiv via injecting drug use in the asia‐pacific region: a longitudinal cohort study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140190/ https://www.ncbi.nlm.nih.gov/pubmed/34021711 http://dx.doi.org/10.1002/jia2.25736 |
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