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A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism

Understanding pharmacokinetic (PK)-pharmacodynamic (PD) relationships is essential in translational research. Existing PK-PD models for combination therapy lack consideration of quantitative contributions from individual drugs, whereas interaction factor is always assigned arbitrarily to one drug an...

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Detalles Bibliográficos
Autores principales:	Choi, Young Hee, Zhang, Chao, Liu, Zhenzhen, Tu, Mei-Juan, Yu, Ai-Xi, Yu, Ai-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Drug Discovery and Translational Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140393/ https://www.ncbi.nlm.nih.gov/pubmed/33712506 http://dx.doi.org/10.1124/jpet.121.000584

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