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ALDH2 polymorphism rs671 is a predictor of PD-1/PD-L1 inhibitor efficacy against thoracic malignancies

BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the endogenous aldehyde detoxification of various types of cells. ALDH2*2, a variant allele of the ALDH2 polymorphism rs671, leads to decreased enzymatic activity. ALDH2*2 may enhance tumor antigen presentation due to aldehyde-i...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Akiko, Nakashima, Chiho, Kimura, Shinya, Sueoka, Eizaburo, Aragane, Naoko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140463/ https://www.ncbi.nlm.nih.gov/pubmed/34022841 http://dx.doi.org/10.1186/s12885-021-08329-y

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