Types of nuclear localization signals and mechanisms of protein import into the nucleus

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear p...

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Autores principales: Lu, Juane, Wu, Tao, Zhang, Biao, Liu, Suke, Song, Wenjun, Qiao, Jianjun, Ruan, Haihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140498/
https://www.ncbi.nlm.nih.gov/pubmed/34022911
http://dx.doi.org/10.1186/s12964-021-00741-y
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author Lu, Juane
Wu, Tao
Zhang, Biao
Liu, Suke
Song, Wenjun
Qiao, Jianjun
Ruan, Haihua
author_facet Lu, Juane
Wu, Tao
Zhang, Biao
Liu, Suke
Song, Wenjun
Qiao, Jianjun
Ruan, Haihua
author_sort Lu, Juane
collection PubMed
description Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00741-y.
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spelling pubmed-81404982021-05-25 Types of nuclear localization signals and mechanisms of protein import into the nucleus Lu, Juane Wu, Tao Zhang, Biao Liu, Suke Song, Wenjun Qiao, Jianjun Ruan, Haihua Cell Commun Signal Review Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00741-y. BioMed Central 2021-05-22 /pmc/articles/PMC8140498/ /pubmed/34022911 http://dx.doi.org/10.1186/s12964-021-00741-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lu, Juane
Wu, Tao
Zhang, Biao
Liu, Suke
Song, Wenjun
Qiao, Jianjun
Ruan, Haihua
Types of nuclear localization signals and mechanisms of protein import into the nucleus
title Types of nuclear localization signals and mechanisms of protein import into the nucleus
title_full Types of nuclear localization signals and mechanisms of protein import into the nucleus
title_fullStr Types of nuclear localization signals and mechanisms of protein import into the nucleus
title_full_unstemmed Types of nuclear localization signals and mechanisms of protein import into the nucleus
title_short Types of nuclear localization signals and mechanisms of protein import into the nucleus
title_sort types of nuclear localization signals and mechanisms of protein import into the nucleus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140498/
https://www.ncbi.nlm.nih.gov/pubmed/34022911
http://dx.doi.org/10.1186/s12964-021-00741-y
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