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Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus
OBJECTIVES: This study aims to explore how disease and health-related quality of life (HRQOL) factors are associated with self-reported physical capacity in walking, jogging and running in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: This cross-sectional study is part of an ongoing coho...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Turkish League Against Rheumatism
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140879/ https://www.ncbi.nlm.nih.gov/pubmed/34046573 http://dx.doi.org/10.46497/ArchRheumatol.2021.8193 |
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author | KINIKLI, Gizem İrem PETTERSSON, Susanne KARAHAN, Sevilay GUNNARSSON, Iva SVENUNGSSON, Elisabet BOSTRÖM, Carina |
author_facet | KINIKLI, Gizem İrem PETTERSSON, Susanne KARAHAN, Sevilay GUNNARSSON, Iva SVENUNGSSON, Elisabet BOSTRÖM, Carina |
author_sort | KINIKLI, Gizem İrem |
collection | PubMed |
description | OBJECTIVES: This study aims to explore how disease and health-related quality of life (HRQOL) factors are associated with self-reported physical capacity in walking, jogging and running in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: This cross-sectional study is part of an ongoing cohort research project which started in 2014. A total of 198 patients (21 males, 177 females; mean age 51.5±16.1 years; range, 20 to 82 years) with SLE answered a question concerning physical capacity and the answers were categorized as low (can walk less than 2 km) and high (can jog and run at least 2 km) capacity. Additional measurements of disease activity (Systemic Lupus Activity Measure-Revised, SLAM-R), organ damage (Systemic Lupus International Collaborating Clinics-Damage Index, SLICC-DI), physical activity (International Physical Activity Questionnaire-Short Form, IPAQ-SF), exercise during the past year, Hospital Anxiety and Depression Scale (HADS), and HRQOL according to EuroQol five-dimension score and EuroQol visual analog scale (EQ-VAS) were included. The independent variables in the multiple logistic regression analysis were age, body mass index (BMI), disease duration, SLAM-R, SLICC-DI, IPAQ-SF category, sitting hours (IPAQ-SF), and exercise during the past year as well as HADS and EQ-VAS. RESULTS: Patients that reported low physical capacity (n=120) were older (p<0.001), had longer disease duration (p<0.001), had more organ damage (p<0.001), reported that they were less physically active (p=0.003), exercised less during the past year (p=0.001), reported more pain/discomfort and depressive symptom (p<0.001) and had lower overall HRQOL (p<0.001) and mobility and usual activities than those that reported high capacity (n=78). The regression analysis showed that age (median ≤49 vs >49) (Exp) (B): 4.52 (95% confidence interval [CI]: 2.05 to 9.98) (p<0.001), disease duration (median ≤17 vs >17) Exp (B): 2.53 (95% CI: 1.15 to 5.60) (p=0.02), SLICC-DI (median <1 vs ≥1) Exp (B): 3.60 (95% CI: 1.48 to 8.73) (p=0.005), and EQ-VAS (median <72 vs ≥72) Exp (B): 4.63 (95% CI: 2.13 to 10.05) (p<0.001) were significant factors associated with physical capacity (Nagelkerke R Squared=0.46). CONCLUSION: Patients with low physical capacity were less physically active, exercised less and had more pain and depressive symptoms than those that reported a high capacity. However, only age, disease duration, organ damage and overall HRQOL were indicators of low physical capacity. In order to increase physical capacity in the management of SLE, it is important to address overall HRQOL. |
format | Online Article Text |
id | pubmed-8140879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Turkish League Against Rheumatism |
record_format | MEDLINE/PubMed |
spelling | pubmed-81408792021-05-26 Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus KINIKLI, Gizem İrem PETTERSSON, Susanne KARAHAN, Sevilay GUNNARSSON, Iva SVENUNGSSON, Elisabet BOSTRÖM, Carina Arch Rheumatol Original Article OBJECTIVES: This study aims to explore how disease and health-related quality of life (HRQOL) factors are associated with self-reported physical capacity in walking, jogging and running in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: This cross-sectional study is part of an ongoing cohort research project which started in 2014. A total of 198 patients (21 males, 177 females; mean age 51.5±16.1 years; range, 20 to 82 years) with SLE answered a question concerning physical capacity and the answers were categorized as low (can walk less than 2 km) and high (can jog and run at least 2 km) capacity. Additional measurements of disease activity (Systemic Lupus Activity Measure-Revised, SLAM-R), organ damage (Systemic Lupus International Collaborating Clinics-Damage Index, SLICC-DI), physical activity (International Physical Activity Questionnaire-Short Form, IPAQ-SF), exercise during the past year, Hospital Anxiety and Depression Scale (HADS), and HRQOL according to EuroQol five-dimension score and EuroQol visual analog scale (EQ-VAS) were included. The independent variables in the multiple logistic regression analysis were age, body mass index (BMI), disease duration, SLAM-R, SLICC-DI, IPAQ-SF category, sitting hours (IPAQ-SF), and exercise during the past year as well as HADS and EQ-VAS. RESULTS: Patients that reported low physical capacity (n=120) were older (p<0.001), had longer disease duration (p<0.001), had more organ damage (p<0.001), reported that they were less physically active (p=0.003), exercised less during the past year (p=0.001), reported more pain/discomfort and depressive symptom (p<0.001) and had lower overall HRQOL (p<0.001) and mobility and usual activities than those that reported high capacity (n=78). The regression analysis showed that age (median ≤49 vs >49) (Exp) (B): 4.52 (95% confidence interval [CI]: 2.05 to 9.98) (p<0.001), disease duration (median ≤17 vs >17) Exp (B): 2.53 (95% CI: 1.15 to 5.60) (p=0.02), SLICC-DI (median <1 vs ≥1) Exp (B): 3.60 (95% CI: 1.48 to 8.73) (p=0.005), and EQ-VAS (median <72 vs ≥72) Exp (B): 4.63 (95% CI: 2.13 to 10.05) (p<0.001) were significant factors associated with physical capacity (Nagelkerke R Squared=0.46). CONCLUSION: Patients with low physical capacity were less physically active, exercised less and had more pain and depressive symptoms than those that reported a high capacity. However, only age, disease duration, organ damage and overall HRQOL were indicators of low physical capacity. In order to increase physical capacity in the management of SLE, it is important to address overall HRQOL. Turkish League Against Rheumatism 2020-12-10 /pmc/articles/PMC8140879/ /pubmed/34046573 http://dx.doi.org/10.46497/ArchRheumatol.2021.8193 Text en Copyright © 2020, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Article KINIKLI, Gizem İrem PETTERSSON, Susanne KARAHAN, Sevilay GUNNARSSON, Iva SVENUNGSSON, Elisabet BOSTRÖM, Carina Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
title | Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
title_full | Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
title_fullStr | Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
title_full_unstemmed | Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
title_short | Factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
title_sort | factors associated with self-reported capacity to walk, jog and run in individuals with systemic lupus erythematosus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140879/ https://www.ncbi.nlm.nih.gov/pubmed/34046573 http://dx.doi.org/10.46497/ArchRheumatol.2021.8193 |
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