Relationship of Histopathological Representation of Excessive Proliferation of Trophoblast Cells with the Possibility of Malignant Events After Complete Hydatidiform Mole

INTRODUCTION: Fifteen to twenty percent of the patients with complete hydatidiform mole transform malignancy into gestational trophoblastic tumors. The marked proliferation of trophoblastic cells is one of the characteristics that determines high risk for the occurrence of post-hydatidiform mole malignancy. The objective of the study was to analyze the histopathologic feature of the marked proliferation of trophoblastic cells as a role in post-hydatidiform mole malignancy that can be used as a determinant of the risk of malignancy post-hydatidiform mole. METHODS: The method of the study was analytical observational with a case–control study design. The data were taken retrospectively from medical records of patients with a post-complete hydatidiform mole malignancy and patients who do not develop post-complete hydatidiform mole malignancy (n = 34). The study took place in the Department of Anatomical Pathology Laboratorium at Dr. Hasan Sadikin Hospital, Bandung, Indonesia. RESULTS: The results showed a highly significant difference with the histopathologic characteristics of marked trophoblastic cell proliferation in post-complete hydatidiform mole malignancy, reaching up to 73.5%. In contrast, the difference between those who do not develop malignancy was 11.8%. The odds ratio (OR) was 20.83, with an interpretation that patients with a complete hydatidiform mole with the histopathological feature of marked trophoblastic cell proliferation had a risk of developing into malignancy 20.83 times higher compared to cases without marked trophoblastic cell proliferation. CONCLUSION: The conclusion of the study was there is a significant correlation between marked trophoblastic cell proliferation with the incidence of post-complete hydatidiform mole malignancy.