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Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village
PURPOSE: Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. CS has been proposed as an underlying mechanism of chronic pain in musculoskeletal disorders including low back pain (LBP). A...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140936/ https://www.ncbi.nlm.nih.gov/pubmed/34040431 http://dx.doi.org/10.2147/JPR.S301924 |
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author | Akeda, Koji Takegami, Norihiko Yamada, Junichi Fujiwara, Tatsuhiko Nishimura, Akinobu Sudo, Akihiro |
author_facet | Akeda, Koji Takegami, Norihiko Yamada, Junichi Fujiwara, Tatsuhiko Nishimura, Akinobu Sudo, Akihiro |
author_sort | Akeda, Koji |
collection | PubMed |
description | PURPOSE: Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. CS has been proposed as an underlying mechanism of chronic pain in musculoskeletal disorders including low back pain (LBP). A Central Sensitization Inventory (CSI) has recently been developed for screening participants with CS. However, the association of CS with chronic LBP (cLBP) in the general population remains unknown. The purpose of this study was to investigate the association of CS with cLBP using the CSI in a population-based cohort of a Japanese mountain village. PARTICIPANTS AND METHODS: Participants aged more than 50 years were recruited from the inhabitants of a mountain village in Japan. Participants completed the following patient-reported outcome measures. Severity of CS was assessed by the CSI. LBP intensity was measured on a numerical rating scale (NRS). Health-related quality of life (QOL) was measured using the EuroQol 5-dimension (EQ-5D), EuroQol-visual analogue scales (EQ-VAS), and the Oswestry Disability Index (ODI). The association of CS and each parameter was statistically evaluated. RESULTS: A total of 272 participants (average age: 72.1 years-old) were analyzed in this study, and 28.3% had cLBP. Average NRS, ODI and CSI scores were significantly higher in the cLBP group than in the without LBP (LBP−) group. There was a significant correlation between CSI and NRS scores (r=0.34, P<0.0001), ODI (r=0.60, P<0.0001), EQ5D (r=−0.55, P<0.0001) and EQ-VAS (r=−0.52, P<0.0001). A multiple regression analysis identified that ODI, EQ-VAS and age were factors significantly associated with CSI. CONCLUSION: The results of this study suggest that CS is involved in the pathological condition of cLBP in the local residents of a Japanese mountain village. |
format | Online Article Text |
id | pubmed-8140936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81409362021-05-25 Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village Akeda, Koji Takegami, Norihiko Yamada, Junichi Fujiwara, Tatsuhiko Nishimura, Akinobu Sudo, Akihiro J Pain Res Original Research PURPOSE: Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. CS has been proposed as an underlying mechanism of chronic pain in musculoskeletal disorders including low back pain (LBP). A Central Sensitization Inventory (CSI) has recently been developed for screening participants with CS. However, the association of CS with chronic LBP (cLBP) in the general population remains unknown. The purpose of this study was to investigate the association of CS with cLBP using the CSI in a population-based cohort of a Japanese mountain village. PARTICIPANTS AND METHODS: Participants aged more than 50 years were recruited from the inhabitants of a mountain village in Japan. Participants completed the following patient-reported outcome measures. Severity of CS was assessed by the CSI. LBP intensity was measured on a numerical rating scale (NRS). Health-related quality of life (QOL) was measured using the EuroQol 5-dimension (EQ-5D), EuroQol-visual analogue scales (EQ-VAS), and the Oswestry Disability Index (ODI). The association of CS and each parameter was statistically evaluated. RESULTS: A total of 272 participants (average age: 72.1 years-old) were analyzed in this study, and 28.3% had cLBP. Average NRS, ODI and CSI scores were significantly higher in the cLBP group than in the without LBP (LBP−) group. There was a significant correlation between CSI and NRS scores (r=0.34, P<0.0001), ODI (r=0.60, P<0.0001), EQ5D (r=−0.55, P<0.0001) and EQ-VAS (r=−0.52, P<0.0001). A multiple regression analysis identified that ODI, EQ-VAS and age were factors significantly associated with CSI. CONCLUSION: The results of this study suggest that CS is involved in the pathological condition of cLBP in the local residents of a Japanese mountain village. Dove 2021-05-18 /pmc/articles/PMC8140936/ /pubmed/34040431 http://dx.doi.org/10.2147/JPR.S301924 Text en © 2021 Akeda et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Akeda, Koji Takegami, Norihiko Yamada, Junichi Fujiwara, Tatsuhiko Nishimura, Akinobu Sudo, Akihiro Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village |
title | Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village |
title_full | Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village |
title_fullStr | Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village |
title_full_unstemmed | Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village |
title_short | Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village |
title_sort | central sensitization in chronic low back pain: a population-based study of a japanese mountain village |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140936/ https://www.ncbi.nlm.nih.gov/pubmed/34040431 http://dx.doi.org/10.2147/JPR.S301924 |
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