Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

ABSTRACT: Euphopepluanones F − K (1 − 4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5 − 12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. T...

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Autores principales: Chen, Yan-Ni, Ding, Xiao, Li, Dong-Mei, Lu, Qing-Yun, Liu, Shuai, Li, Ying-Yao, Di, Ying-Tong, Fang, Xin, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140953/
https://www.ncbi.nlm.nih.gov/pubmed/33719014
http://dx.doi.org/10.1007/s13659-021-00301-4
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author Chen, Yan-Ni
Ding, Xiao
Li, Dong-Mei
Lu, Qing-Yun
Liu, Shuai
Li, Ying-Yao
Di, Ying-Tong
Fang, Xin
Hao, Xiao-Jiang
author_facet Chen, Yan-Ni
Ding, Xiao
Li, Dong-Mei
Lu, Qing-Yun
Liu, Shuai
Li, Ying-Yao
Di, Ying-Tong
Fang, Xin
Hao, Xiao-Jiang
author_sort Chen, Yan-Ni
collection PubMed
description ABSTRACT: Euphopepluanones F − K (1 − 4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5 − 12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1 − 4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00301-4.
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spelling pubmed-81409532021-06-07 Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway Chen, Yan-Ni Ding, Xiao Li, Dong-Mei Lu, Qing-Yun Liu, Shuai Li, Ying-Yao Di, Ying-Tong Fang, Xin Hao, Xiao-Jiang Nat Prod Bioprospect Original Article ABSTRACT: Euphopepluanones F − K (1 − 4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5 − 12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1 − 4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00301-4. Springer Singapore 2021-03-14 /pmc/articles/PMC8140953/ /pubmed/33719014 http://dx.doi.org/10.1007/s13659-021-00301-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Chen, Yan-Ni
Ding, Xiao
Li, Dong-Mei
Lu, Qing-Yun
Liu, Shuai
Li, Ying-Yao
Di, Ying-Tong
Fang, Xin
Hao, Xiao-Jiang
Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
title Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
title_full Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
title_fullStr Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
title_full_unstemmed Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
title_short Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
title_sort jatrophane diterpenoids from the seeds of euphorbia peplus with potential bioactivities in lysosomal-autophagy pathway
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140953/
https://www.ncbi.nlm.nih.gov/pubmed/33719014
http://dx.doi.org/10.1007/s13659-021-00301-4
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