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A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome
Several lines of evidence indicate that immune-inflammatory alterations are widely observed in various mental disorders. Genetic syndromes with high risk of psychiatric disorders may constitute a model for studies investigating this phenomenon. One of such genetically determined neurodevelopmental d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140962/ https://www.ncbi.nlm.nih.gov/pubmed/32495042 http://dx.doi.org/10.1007/s00787-020-01568-7 |
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author | Krefft, Maja Frydecka, Dorota Zalsman, Gil Krzystek-Korpacka, Małgorzata Śmigiel, Robert Gębura, Katarzyna Bogunia-Kubik, Katarzyna Misiak, Błażej |
author_facet | Krefft, Maja Frydecka, Dorota Zalsman, Gil Krzystek-Korpacka, Małgorzata Śmigiel, Robert Gębura, Katarzyna Bogunia-Kubik, Katarzyna Misiak, Błażej |
author_sort | Krefft, Maja |
collection | PubMed |
description | Several lines of evidence indicate that immune-inflammatory alterations are widely observed in various mental disorders. Genetic syndromes with high risk of psychiatric disorders may constitute a model for studies investigating this phenomenon. One of such genetically determined neurodevelopmental disorders is the Prader–Willi syndrome (PWS). Therefore, we aimed to profile a broad panel of immune-inflammatory markers in patients with PWS, taking into account co-morbid psychopathology. Participants were 20 children with PWS, and 20 healthy children matched for age, sex and body mass index. Behavioural symptoms and co-occurring psychopathological symptoms were assessed using the Child Behaviour Checklist (CBCL). We found significantly elevated levels of interleukin (IL)-1β and IL-13 in patients with PWS. There were significant positive correlations between the levels of IL-1β and scores of the following externalizing and internalizing CBCL domains: withdrawn/depressed, social problems, thought problems, attention problems, delinquent and aggressive behaviour in PWS children. Moreover, higher levels of IL-13 were associated with more severe psychopathology in terms of social and attention problems as well as delinquent and aggressive behaviour. Our findings imply that subclinical inflammation, observed as elevated IL-1β and IL-13 levels, appears only in PWS patients and is correlated to several psychopathological symptoms. |
format | Online Article Text |
id | pubmed-8140962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81409622021-06-03 A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome Krefft, Maja Frydecka, Dorota Zalsman, Gil Krzystek-Korpacka, Małgorzata Śmigiel, Robert Gębura, Katarzyna Bogunia-Kubik, Katarzyna Misiak, Błażej Eur Child Adolesc Psychiatry Original Contribution Several lines of evidence indicate that immune-inflammatory alterations are widely observed in various mental disorders. Genetic syndromes with high risk of psychiatric disorders may constitute a model for studies investigating this phenomenon. One of such genetically determined neurodevelopmental disorders is the Prader–Willi syndrome (PWS). Therefore, we aimed to profile a broad panel of immune-inflammatory markers in patients with PWS, taking into account co-morbid psychopathology. Participants were 20 children with PWS, and 20 healthy children matched for age, sex and body mass index. Behavioural symptoms and co-occurring psychopathological symptoms were assessed using the Child Behaviour Checklist (CBCL). We found significantly elevated levels of interleukin (IL)-1β and IL-13 in patients with PWS. There were significant positive correlations between the levels of IL-1β and scores of the following externalizing and internalizing CBCL domains: withdrawn/depressed, social problems, thought problems, attention problems, delinquent and aggressive behaviour in PWS children. Moreover, higher levels of IL-13 were associated with more severe psychopathology in terms of social and attention problems as well as delinquent and aggressive behaviour. Our findings imply that subclinical inflammation, observed as elevated IL-1β and IL-13 levels, appears only in PWS patients and is correlated to several psychopathological symptoms. Springer Berlin Heidelberg 2020-06-03 2021 /pmc/articles/PMC8140962/ /pubmed/32495042 http://dx.doi.org/10.1007/s00787-020-01568-7 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Contribution Krefft, Maja Frydecka, Dorota Zalsman, Gil Krzystek-Korpacka, Małgorzata Śmigiel, Robert Gębura, Katarzyna Bogunia-Kubik, Katarzyna Misiak, Błażej A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome |
title | A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome |
title_full | A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome |
title_fullStr | A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome |
title_full_unstemmed | A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome |
title_short | A pro-inflammatory phenotype is associated with behavioural traits in children with Prader–Willi syndrome |
title_sort | pro-inflammatory phenotype is associated with behavioural traits in children with prader–willi syndrome |
topic | Original Contribution |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140962/ https://www.ncbi.nlm.nih.gov/pubmed/32495042 http://dx.doi.org/10.1007/s00787-020-01568-7 |
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