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Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes
BACKGROUND: Management of patients treated with Ticagrelor is challenging, as stopping Ticagrelor prior to coronary bypass graft surgery (CABG) may increase the risk of acute stent thrombosis. The aim of the study was to compare bleeding complications in patients treated with ticagrelor combined wit...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141141/ https://www.ncbi.nlm.nih.gov/pubmed/34022927 http://dx.doi.org/10.1186/s13019-021-01521-y |
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author | Diab, Sammer Arazi, Mattan Sternik, Leonid Raanani, Ehud Kachel, Erez Grosman-Rimon, Liza Shalabi, Amjad Amir, Offer Carasso, Shemy |
author_facet | Diab, Sammer Arazi, Mattan Sternik, Leonid Raanani, Ehud Kachel, Erez Grosman-Rimon, Liza Shalabi, Amjad Amir, Offer Carasso, Shemy |
author_sort | Diab, Sammer |
collection | PubMed |
description | BACKGROUND: Management of patients treated with Ticagrelor is challenging, as stopping Ticagrelor prior to coronary bypass graft surgery (CABG) may increase the risk of acute stent thrombosis. The aim of the study was to compare bleeding complications in patients treated with ticagrelor combined with acetylsalicylic acid (ASA) versus ASA alone until 1 day before surgery. METHODS: Bleeding complications, defined as the composite of red blood cell transfusion ≥1000 ml, chest drainage ≥2000 ml, and bleeding requiring surgical re-exploration, were compared in 161 patients, with 101 on preoperative acetylsalicylic acid (ASA) alone (group A) and 65 on ticagrelor + ASA (group B). RESULTS: There were no differences in bleeding complications between the two groups (26% vs. 27% in group A and B, respectively), with similar chest drainage in the first 24 h (569 ± 393 ml and 649 ± 427 ml, respectively). CONCLUSIONS: Continuing ticagrelor until coronary artery bypass surgery was not associated with increased bleeding complications, suggesting that continued management with ticagrelor until surgery may be safe. |
format | Online Article Text |
id | pubmed-8141141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81411412021-05-25 Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes Diab, Sammer Arazi, Mattan Sternik, Leonid Raanani, Ehud Kachel, Erez Grosman-Rimon, Liza Shalabi, Amjad Amir, Offer Carasso, Shemy J Cardiothorac Surg Research Article BACKGROUND: Management of patients treated with Ticagrelor is challenging, as stopping Ticagrelor prior to coronary bypass graft surgery (CABG) may increase the risk of acute stent thrombosis. The aim of the study was to compare bleeding complications in patients treated with ticagrelor combined with acetylsalicylic acid (ASA) versus ASA alone until 1 day before surgery. METHODS: Bleeding complications, defined as the composite of red blood cell transfusion ≥1000 ml, chest drainage ≥2000 ml, and bleeding requiring surgical re-exploration, were compared in 161 patients, with 101 on preoperative acetylsalicylic acid (ASA) alone (group A) and 65 on ticagrelor + ASA (group B). RESULTS: There were no differences in bleeding complications between the two groups (26% vs. 27% in group A and B, respectively), with similar chest drainage in the first 24 h (569 ± 393 ml and 649 ± 427 ml, respectively). CONCLUSIONS: Continuing ticagrelor until coronary artery bypass surgery was not associated with increased bleeding complications, suggesting that continued management with ticagrelor until surgery may be safe. BioMed Central 2021-05-22 /pmc/articles/PMC8141141/ /pubmed/34022927 http://dx.doi.org/10.1186/s13019-021-01521-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Diab, Sammer Arazi, Mattan Sternik, Leonid Raanani, Ehud Kachel, Erez Grosman-Rimon, Liza Shalabi, Amjad Amir, Offer Carasso, Shemy Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
title | Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
title_full | Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
title_fullStr | Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
title_full_unstemmed | Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
title_short | Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
title_sort | coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141141/ https://www.ncbi.nlm.nih.gov/pubmed/34022927 http://dx.doi.org/10.1186/s13019-021-01521-y |
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