Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report

BACKGROUND: We report a rare case of malignant phyllodes tumors (MPT) with partial response to apatinib. CASE PRESENTATION: A 26-year-old woman had a palpable mass in her right breast for over a year. After resection, pathology indicated malignant phyllodes tumor. Eleven months after surgery, she un...

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Autores principales: Wang, Xiaolu, Xie, Li, Hu, Wenjing, Yan, Jing, Qian, Xiaoping, Zhu, Lijing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141161/
https://www.ncbi.nlm.nih.gov/pubmed/34022875
http://dx.doi.org/10.1186/s12905-021-01359-5
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author Wang, Xiaolu
Xie, Li
Hu, Wenjing
Yan, Jing
Qian, Xiaoping
Zhu, Lijing
author_facet Wang, Xiaolu
Xie, Li
Hu, Wenjing
Yan, Jing
Qian, Xiaoping
Zhu, Lijing
author_sort Wang, Xiaolu
collection PubMed
description BACKGROUND: We report a rare case of malignant phyllodes tumors (MPT) with partial response to apatinib. CASE PRESENTATION: A 26-year-old woman had a palpable mass in her right breast for over a year. After resection, pathology indicated malignant phyllodes tumor. Eleven months after surgery, she underwent reoperation for a lung nodule, which demonstrated lung metastasis. She refused chemotherapy and was rehospitalized six months later due to leg pain. Pelvic mass biopsy revealed metastatic malignant phyllodes tumor. After concurrent chemoradiotherapy of the pelvic mass, multiple lung metastases emerged. Subsequent treatment with apatinib 500 mg/day resulted in a reduction in mass size and partial response. She survived for more than 8 months. CONCLUSION: The present case showed the potential therapeutic effects of apatinib in patients with MPT.
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spelling pubmed-81411612021-05-25 Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report Wang, Xiaolu Xie, Li Hu, Wenjing Yan, Jing Qian, Xiaoping Zhu, Lijing BMC Womens Health Case Report BACKGROUND: We report a rare case of malignant phyllodes tumors (MPT) with partial response to apatinib. CASE PRESENTATION: A 26-year-old woman had a palpable mass in her right breast for over a year. After resection, pathology indicated malignant phyllodes tumor. Eleven months after surgery, she underwent reoperation for a lung nodule, which demonstrated lung metastasis. She refused chemotherapy and was rehospitalized six months later due to leg pain. Pelvic mass biopsy revealed metastatic malignant phyllodes tumor. After concurrent chemoradiotherapy of the pelvic mass, multiple lung metastases emerged. Subsequent treatment with apatinib 500 mg/day resulted in a reduction in mass size and partial response. She survived for more than 8 months. CONCLUSION: The present case showed the potential therapeutic effects of apatinib in patients with MPT. BioMed Central 2021-05-22 /pmc/articles/PMC8141161/ /pubmed/34022875 http://dx.doi.org/10.1186/s12905-021-01359-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Wang, Xiaolu
Xie, Li
Hu, Wenjing
Yan, Jing
Qian, Xiaoping
Zhu, Lijing
Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
title Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
title_full Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
title_fullStr Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
title_full_unstemmed Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
title_short Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
title_sort apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141161/
https://www.ncbi.nlm.nih.gov/pubmed/34022875
http://dx.doi.org/10.1186/s12905-021-01359-5
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AT yanjing apatinibtreatmentiseffectiveformetastaticmalignantphyllodestumorsofthebreastacasereport
AT qianxiaoping apatinibtreatmentiseffectiveformetastaticmalignantphyllodestumorsofthebreastacasereport
AT zhulijing apatinibtreatmentiseffectiveformetastaticmalignantphyllodestumorsofthebreastacasereport

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