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What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts
Despite promising candidates for new therapeutic options in the treatment of systemic lupus erythematosus (SLE), many clinical trials have failed in the past few years. The disappointing results have been at least partly be attributed to trial designs. With the aim of stimulating new developments in...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141446/ https://www.ncbi.nlm.nih.gov/pubmed/34016719 http://dx.doi.org/10.1136/lupus-2021-000506 |
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author | Mucke, Johanna Alarcon-Riquelme, Marta Andersen, Jeanette Aringer, Martin Bombardieri, Stefano Brinks, Ralph Cervera, Ricard Chehab, Gamal Cornet, Alain Costedoat-Chalumeau, Nathalie Czirják, László Doria, Andrea Fischer-Betz, Rebecca Furie, Richard A Gatto, Mariele Houssiau, Frédéric A Ines, Luis Liang, Matthew H Morand, Eric Mosca, Marta Pego-Reigosa, José María Rúa-Figueroa, Iñigo Ruiz-Irastorza, Guillermo Terrier, Benjamin Voss, Anne Schneider, Matthias |
author_facet | Mucke, Johanna Alarcon-Riquelme, Marta Andersen, Jeanette Aringer, Martin Bombardieri, Stefano Brinks, Ralph Cervera, Ricard Chehab, Gamal Cornet, Alain Costedoat-Chalumeau, Nathalie Czirják, László Doria, Andrea Fischer-Betz, Rebecca Furie, Richard A Gatto, Mariele Houssiau, Frédéric A Ines, Luis Liang, Matthew H Morand, Eric Mosca, Marta Pego-Reigosa, José María Rúa-Figueroa, Iñigo Ruiz-Irastorza, Guillermo Terrier, Benjamin Voss, Anne Schneider, Matthias |
author_sort | Mucke, Johanna |
collection | PubMed |
description | Despite promising candidates for new therapeutic options in the treatment of systemic lupus erythematosus (SLE), many clinical trials have failed in the past few years. The disappointing results have been at least partly be attributed to trial designs. With the aim of stimulating new developments in SLE trial design, an international open space meeting was held on occasion of the European Lupus Meeting 2018 in Duesseldorf, Germany about ‘What are the topics you care about for making trials in lupus more effective?’. The Open Space is a participant-driven technology, where the discussion topics and schedule are selected during the meeting by all participants and discussion rounds are led by the people attending encouraging active contributions. Eleven topics were selected for further discussion, of which 6 were voted to be more intensively discussed in two consecutive rounds. Major topics were the optimal handling of glucocorticoids in clinical trials, the improvement of outcome measures, reducing or controlling the placebo response and the identification of biomarkers and stratification parameters. Further, the importance of local and international networks was emphasised. By networking, collaborations are facilitated, patient recruitment is more efficient and treatment can be harmonised thus lead to more successful SLE trials. Further discussions are needed to substantiate the results and develop new trial designs. |
format | Online Article Text |
id | pubmed-8141446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-81414462021-06-07 What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts Mucke, Johanna Alarcon-Riquelme, Marta Andersen, Jeanette Aringer, Martin Bombardieri, Stefano Brinks, Ralph Cervera, Ricard Chehab, Gamal Cornet, Alain Costedoat-Chalumeau, Nathalie Czirják, László Doria, Andrea Fischer-Betz, Rebecca Furie, Richard A Gatto, Mariele Houssiau, Frédéric A Ines, Luis Liang, Matthew H Morand, Eric Mosca, Marta Pego-Reigosa, José María Rúa-Figueroa, Iñigo Ruiz-Irastorza, Guillermo Terrier, Benjamin Voss, Anne Schneider, Matthias Lupus Sci Med Meeting Report Despite promising candidates for new therapeutic options in the treatment of systemic lupus erythematosus (SLE), many clinical trials have failed in the past few years. The disappointing results have been at least partly be attributed to trial designs. With the aim of stimulating new developments in SLE trial design, an international open space meeting was held on occasion of the European Lupus Meeting 2018 in Duesseldorf, Germany about ‘What are the topics you care about for making trials in lupus more effective?’. The Open Space is a participant-driven technology, where the discussion topics and schedule are selected during the meeting by all participants and discussion rounds are led by the people attending encouraging active contributions. Eleven topics were selected for further discussion, of which 6 were voted to be more intensively discussed in two consecutive rounds. Major topics were the optimal handling of glucocorticoids in clinical trials, the improvement of outcome measures, reducing or controlling the placebo response and the identification of biomarkers and stratification parameters. Further, the importance of local and international networks was emphasised. By networking, collaborations are facilitated, patient recruitment is more efficient and treatment can be harmonised thus lead to more successful SLE trials. Further discussions are needed to substantiate the results and develop new trial designs. BMJ Publishing Group 2021-05-20 /pmc/articles/PMC8141446/ /pubmed/34016719 http://dx.doi.org/10.1136/lupus-2021-000506 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Meeting Report Mucke, Johanna Alarcon-Riquelme, Marta Andersen, Jeanette Aringer, Martin Bombardieri, Stefano Brinks, Ralph Cervera, Ricard Chehab, Gamal Cornet, Alain Costedoat-Chalumeau, Nathalie Czirják, László Doria, Andrea Fischer-Betz, Rebecca Furie, Richard A Gatto, Mariele Houssiau, Frédéric A Ines, Luis Liang, Matthew H Morand, Eric Mosca, Marta Pego-Reigosa, José María Rúa-Figueroa, Iñigo Ruiz-Irastorza, Guillermo Terrier, Benjamin Voss, Anne Schneider, Matthias What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts |
title | What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts |
title_full | What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts |
title_fullStr | What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts |
title_full_unstemmed | What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts |
title_short | What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts |
title_sort | what are the topics you care about making trials in lupus more effective? results of an open space meeting of international lupus experts |
topic | Meeting Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141446/ https://www.ncbi.nlm.nih.gov/pubmed/34016719 http://dx.doi.org/10.1136/lupus-2021-000506 |
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