An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib

Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia. Chromosomal abnormalities are reported to play important roles in CLL pathogenesis and evolution, including deletions of 11q, 13q, 17p, and trisomy12, that are frequently observed and have a known prognostic value. Further...

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Autores principales: Haddad, Fady Gh, Chebly, Alain, El Sett, Antoine, Kourie, Hampig Raphael, Farra, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141474/
https://www.ncbi.nlm.nih.gov/pubmed/34040960
http://dx.doi.org/10.1016/j.lrr.2021.100245
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author Haddad, Fady Gh
Chebly, Alain
El Sett, Antoine
Kourie, Hampig Raphael
Farra, Chantal
author_facet Haddad, Fady Gh
Chebly, Alain
El Sett, Antoine
Kourie, Hampig Raphael
Farra, Chantal
author_sort Haddad, Fady Gh
collection PubMed
description Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia. Chromosomal abnormalities are reported to play important roles in CLL pathogenesis and evolution, including deletions of 11q, 13q, 17p, and trisomy12, that are frequently observed and have a known prognostic value. Furthermore, the mutational status of the IGHV gene was reported as an independent prognostic marker in CLL impacting the choice of therapy. We herein, report an unusual presentation of a Lebanese CLL patient with two cytogenetic abnormalities: trisomy 12 and t(14;18)(q32;q21), along with an unmutated IGHV, displaying a favorable response to ibrutinib with a maintained complete remission.
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spelling pubmed-81414742021-05-25 An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib Haddad, Fady Gh Chebly, Alain El Sett, Antoine Kourie, Hampig Raphael Farra, Chantal Leuk Res Rep Article Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia. Chromosomal abnormalities are reported to play important roles in CLL pathogenesis and evolution, including deletions of 11q, 13q, 17p, and trisomy12, that are frequently observed and have a known prognostic value. Furthermore, the mutational status of the IGHV gene was reported as an independent prognostic marker in CLL impacting the choice of therapy. We herein, report an unusual presentation of a Lebanese CLL patient with two cytogenetic abnormalities: trisomy 12 and t(14;18)(q32;q21), along with an unmutated IGHV, displaying a favorable response to ibrutinib with a maintained complete remission. Elsevier 2021-05-11 /pmc/articles/PMC8141474/ /pubmed/34040960 http://dx.doi.org/10.1016/j.lrr.2021.100245 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Haddad, Fady Gh
Chebly, Alain
El Sett, Antoine
Kourie, Hampig Raphael
Farra, Chantal
An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
title An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
title_full An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
title_fullStr An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
title_full_unstemmed An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
title_short An unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
title_sort unusual case of chronic lymphocytic leukemia with trisomy 12 and t(14;18) and a favorable response to ibrutinib
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141474/
https://www.ncbi.nlm.nih.gov/pubmed/34040960
http://dx.doi.org/10.1016/j.lrr.2021.100245
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