NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases

Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune and inflammatory diseases. NKTR-358, a novel regulatory T-cell stimulator, is an investigational therapeutic that selectively...

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Detalles Bibliográficos
Autores principales: Dixit, Neha, Fanton, Christie, Langowski, John L., Kirksey, Yolanda, Kirk, Peter, Chang, Thomas, Cetz, Janet, Dixit, Vidula, Kim, Grace, Kuo, Peiwen, Maiti, Mekhala, Tang, Yinyan, VanderVeen, Laurie A., Zhang, Ping, Lee, Myong, Ritz, Jerome, Kamihara, Yusuke, Ji, Chunmei, Rubas, Werner, Sweeney, Theresa D., Doberstein, Stephen K., Zalevsky, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141531/
https://www.ncbi.nlm.nih.gov/pubmed/34041473
http://dx.doi.org/10.1016/j.jtauto.2021.100103

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