Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions

ADP-ribosylation is a reversible and site-specific post-translational modification that regulates a wide array of cellular signaling pathways. Regulation of ADP-ribosylation is vital for maintaining genomic integrity, and uncontrolled accumulation of poly(ADP-ribosyl)ation triggers a poly(ADP-ribose...

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Detalles Bibliográficos
Autores principales: Pourfarjam, Yasin, Ma, Zhijun, Kurinov, Igor, Moss, Joel, Kim, In-Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141533/
https://www.ncbi.nlm.nih.gov/pubmed/33894202
http://dx.doi.org/10.1016/j.jbc.2021.100692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141533/
https://www.ncbi.nlm.nih.gov/pubmed/33894202
http://dx.doi.org/10.1016/j.jbc.2021.100692

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