Cargando…

Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study

Aims: To evaluate the prospective association of circulating PCSK9 levels with the cardiometabolic risk profiles (high LDL-cholesterol, high triglycerides, low HDL-cholesterol, hypertension, type 2 diabetes, and metabolic syndrome). Methods: A population-based prospective study was conducted among 7...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Jie, Li, Xiaoyong, Zhang, Weiwei, Niu, Yixin, Lin, Ning, Zhang, Hongmei, Ning, Guang, Fan, Jiangao, Qin, Li, Su, Qing, Yang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141620/
https://www.ncbi.nlm.nih.gov/pubmed/34041285
http://dx.doi.org/10.3389/fcvm.2021.664583
_version_ 1783696401227579392
author Shi, Jie
Li, Xiaoyong
Zhang, Weiwei
Niu, Yixin
Lin, Ning
Zhang, Hongmei
Ning, Guang
Fan, Jiangao
Qin, Li
Su, Qing
Yang, Zhen
author_facet Shi, Jie
Li, Xiaoyong
Zhang, Weiwei
Niu, Yixin
Lin, Ning
Zhang, Hongmei
Ning, Guang
Fan, Jiangao
Qin, Li
Su, Qing
Yang, Zhen
author_sort Shi, Jie
collection PubMed
description Aims: To evaluate the prospective association of circulating PCSK9 levels with the cardiometabolic risk profiles (high LDL-cholesterol, high triglycerides, low HDL-cholesterol, hypertension, type 2 diabetes, and metabolic syndrome). Methods: A population-based prospective study was conducted among 7,104 Chinese individuals (age 56.2 ± 7.5 years; 32.0% men). Circulating PCSK9 levels were measured using ELISA. Results: Circulating PCSK9 levels were higher in women than men (286.7 ± 90.1 vs. 276.1 ± 86.4 ng/ml, p < 0.001). And circulating PCSK9 was positively correlated with LDL-cholesterol, total cholesterol, and triglycerides both in men and women (all p < 0.001). The positive correlation between PCSK9 and waist circumference, fasting glucose, insulin resistance, systolic blood pressure, diastolic blood pressure and C-reactive protein (all p < 0.01) was observed in women only. According to Cox regression analysis, circulating PCSK9 was positively associated with incidence of high LDL-cholesterol both in men (HR 1.33, 95% CI 1.09–1.65, p < 0.001) and women (HR 1.36, 95% CI 1.12–1.69, p < 0.001). Moreover, PCSK9 was significantly associated with incident high triglycerides (HR 1.31, 95% CI 1.13–1.72, p < 0.001), hypertension (HR 1.28, 95% CI 1.08–1.53, p = 0.011), type 2 diabetes (HR 1.34, 95% CI 1.09–1.76, p = 0.005), and metabolic syndrome (HR 1.30, 95% CI 1.11–1.65, p = 0.009) per SD change in women only. No statistically significant association was observed between circulating PCSK9 and incidence of low HDL-cholesterol (p > 0.1). Conclusions: Elevated circulating PCSK9 was significantly associated with cardiometabolic risk factors and independently contributed to the prediction of cardiometabolic risks in women.
format Online
Article
Text
id pubmed-8141620
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81416202021-05-25 Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study Shi, Jie Li, Xiaoyong Zhang, Weiwei Niu, Yixin Lin, Ning Zhang, Hongmei Ning, Guang Fan, Jiangao Qin, Li Su, Qing Yang, Zhen Front Cardiovasc Med Cardiovascular Medicine Aims: To evaluate the prospective association of circulating PCSK9 levels with the cardiometabolic risk profiles (high LDL-cholesterol, high triglycerides, low HDL-cholesterol, hypertension, type 2 diabetes, and metabolic syndrome). Methods: A population-based prospective study was conducted among 7,104 Chinese individuals (age 56.2 ± 7.5 years; 32.0% men). Circulating PCSK9 levels were measured using ELISA. Results: Circulating PCSK9 levels were higher in women than men (286.7 ± 90.1 vs. 276.1 ± 86.4 ng/ml, p < 0.001). And circulating PCSK9 was positively correlated with LDL-cholesterol, total cholesterol, and triglycerides both in men and women (all p < 0.001). The positive correlation between PCSK9 and waist circumference, fasting glucose, insulin resistance, systolic blood pressure, diastolic blood pressure and C-reactive protein (all p < 0.01) was observed in women only. According to Cox regression analysis, circulating PCSK9 was positively associated with incidence of high LDL-cholesterol both in men (HR 1.33, 95% CI 1.09–1.65, p < 0.001) and women (HR 1.36, 95% CI 1.12–1.69, p < 0.001). Moreover, PCSK9 was significantly associated with incident high triglycerides (HR 1.31, 95% CI 1.13–1.72, p < 0.001), hypertension (HR 1.28, 95% CI 1.08–1.53, p = 0.011), type 2 diabetes (HR 1.34, 95% CI 1.09–1.76, p = 0.005), and metabolic syndrome (HR 1.30, 95% CI 1.11–1.65, p = 0.009) per SD change in women only. No statistically significant association was observed between circulating PCSK9 and incidence of low HDL-cholesterol (p > 0.1). Conclusions: Elevated circulating PCSK9 was significantly associated with cardiometabolic risk factors and independently contributed to the prediction of cardiometabolic risks in women. Frontiers Media S.A. 2021-05-10 /pmc/articles/PMC8141620/ /pubmed/34041285 http://dx.doi.org/10.3389/fcvm.2021.664583 Text en Copyright © 2021 Shi, Li, Zhang, Niu, Lin, Zhang, Ning, Fan, Qin, Su and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Shi, Jie
Li, Xiaoyong
Zhang, Weiwei
Niu, Yixin
Lin, Ning
Zhang, Hongmei
Ning, Guang
Fan, Jiangao
Qin, Li
Su, Qing
Yang, Zhen
Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
title Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
title_full Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
title_fullStr Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
title_full_unstemmed Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
title_short Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
title_sort circulating proprotein convertase subtilisin/kexin type 9 levels and cardiometabolic risk factors: a population-based cohort study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141620/
https://www.ncbi.nlm.nih.gov/pubmed/34041285
http://dx.doi.org/10.3389/fcvm.2021.664583
work_keys_str_mv AT shijie circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT lixiaoyong circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT zhangweiwei circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT niuyixin circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT linning circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT zhanghongmei circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT ningguang circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT fanjiangao circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT qinli circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT suqing circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy
AT yangzhen circulatingproproteinconvertasesubtilisinkexintype9levelsandcardiometabolicriskfactorsapopulationbasedcohortstudy