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Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample

Recent studies suggest that the endocannabinoid system could play an important role in the physiopathology of obsessive-compulsive disorder (OCD). There are reports of effective treatment with derivatives of tetrahydrocannabinol (THC). The study of the genetic factor associated with psychiatric diso...

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Autores principales: Nicolini, Humberto, Martínez-Magaña, José Jaime, Genis-Mendoza, Alma Delia, Villatoro Velázquez, Jorge Ameth, Camarena, Beatriz, Fleiz Bautista, Clara, Bustos-Gamiño, Marycarmen, Aguilar García, Alejandro, Lanzagorta, Nuria, Medina-Mora, María Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141625/
https://www.ncbi.nlm.nih.gov/pubmed/34040556
http://dx.doi.org/10.3389/fpsyt.2021.664228
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author Nicolini, Humberto
Martínez-Magaña, José Jaime
Genis-Mendoza, Alma Delia
Villatoro Velázquez, Jorge Ameth
Camarena, Beatriz
Fleiz Bautista, Clara
Bustos-Gamiño, Marycarmen
Aguilar García, Alejandro
Lanzagorta, Nuria
Medina-Mora, María Elena
author_facet Nicolini, Humberto
Martínez-Magaña, José Jaime
Genis-Mendoza, Alma Delia
Villatoro Velázquez, Jorge Ameth
Camarena, Beatriz
Fleiz Bautista, Clara
Bustos-Gamiño, Marycarmen
Aguilar García, Alejandro
Lanzagorta, Nuria
Medina-Mora, María Elena
author_sort Nicolini, Humberto
collection PubMed
description Recent studies suggest that the endocannabinoid system could play an important role in the physiopathology of obsessive-compulsive disorder (OCD). There are reports of effective treatment with derivatives of tetrahydrocannabinol (THC). The study of the genetic factor associated with psychiatric disorders has made possible an exploration of its contribution to the pharmacological response. However, very little is known about the genetic factor or the prevalence of cannabis use in the Mexican population with OCD. The objective of this study is to compare the prevalence of use and dependence on cannabis in individuals with obsessive-compulsive symptomatology (OCS) with that of individuals with other psychiatric symptoms (psychosis, depression, and anxiety), and to explore the association between genetic risk and use. The study includes a total of 13,130 individuals evaluated in the second stage of the 2016 National Survey of Drug, Alcohol, and Tobacco Use (Encodat 2016), with genetic analysis (polygenic risk scoring) of a subsample of 3,521 individuals. Obsessive symptomatology had a prevalence of 7.2% and compulsive symptomatology a prevalence of 8.6%. The proportion of individuals with OCS who had ever used cannabis was 23.4%, and of those with cannabis dependency was 2.7%, the latter figure higher than that in individuals with other psychiatric symptoms (hypomania, 2.6%; anxiety, 2.8%; depression, 2.3%), except psychosis (5.9%). Individuals with OCS who reported using cannabis had an increased genetic risk for cannabis dependence but not for OCD. We thus cannot know how the increased genetic risk of cannabis dependence in people with OCD is influenced by their pharmacological response to derivatives of THC. The results, however, suggest paths for future studies.
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spelling pubmed-81416252021-05-25 Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample Nicolini, Humberto Martínez-Magaña, José Jaime Genis-Mendoza, Alma Delia Villatoro Velázquez, Jorge Ameth Camarena, Beatriz Fleiz Bautista, Clara Bustos-Gamiño, Marycarmen Aguilar García, Alejandro Lanzagorta, Nuria Medina-Mora, María Elena Front Psychiatry Psychiatry Recent studies suggest that the endocannabinoid system could play an important role in the physiopathology of obsessive-compulsive disorder (OCD). There are reports of effective treatment with derivatives of tetrahydrocannabinol (THC). The study of the genetic factor associated with psychiatric disorders has made possible an exploration of its contribution to the pharmacological response. However, very little is known about the genetic factor or the prevalence of cannabis use in the Mexican population with OCD. The objective of this study is to compare the prevalence of use and dependence on cannabis in individuals with obsessive-compulsive symptomatology (OCS) with that of individuals with other psychiatric symptoms (psychosis, depression, and anxiety), and to explore the association between genetic risk and use. The study includes a total of 13,130 individuals evaluated in the second stage of the 2016 National Survey of Drug, Alcohol, and Tobacco Use (Encodat 2016), with genetic analysis (polygenic risk scoring) of a subsample of 3,521 individuals. Obsessive symptomatology had a prevalence of 7.2% and compulsive symptomatology a prevalence of 8.6%. The proportion of individuals with OCS who had ever used cannabis was 23.4%, and of those with cannabis dependency was 2.7%, the latter figure higher than that in individuals with other psychiatric symptoms (hypomania, 2.6%; anxiety, 2.8%; depression, 2.3%), except psychosis (5.9%). Individuals with OCS who reported using cannabis had an increased genetic risk for cannabis dependence but not for OCD. We thus cannot know how the increased genetic risk of cannabis dependence in people with OCD is influenced by their pharmacological response to derivatives of THC. The results, however, suggest paths for future studies. Frontiers Media S.A. 2021-05-10 /pmc/articles/PMC8141625/ /pubmed/34040556 http://dx.doi.org/10.3389/fpsyt.2021.664228 Text en Copyright © 2021 Nicolini, Martínez-Magaña, Genis-Mendoza, Villatoro Velázquez, Camarena, Fleiz Bautista, Bustos-Gamiño, Aguilar García, Lanzagorta and Medina-Mora. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Nicolini, Humberto
Martínez-Magaña, José Jaime
Genis-Mendoza, Alma Delia
Villatoro Velázquez, Jorge Ameth
Camarena, Beatriz
Fleiz Bautista, Clara
Bustos-Gamiño, Marycarmen
Aguilar García, Alejandro
Lanzagorta, Nuria
Medina-Mora, María Elena
Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
title Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
title_full Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
title_fullStr Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
title_full_unstemmed Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
title_short Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
title_sort cannabis use in people with obsessive-compulsive symptomatology: results from a mexican epidemiological sample
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141625/
https://www.ncbi.nlm.nih.gov/pubmed/34040556
http://dx.doi.org/10.3389/fpsyt.2021.664228
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