Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice

Cardiosphere-derived cell exosomes (CDC(exo)) and YF1, a CDC(exo)-derived non-coding RNA, elicit therapeutic bioactivity in models of myocardial infarction and hypertensive hypertrophy. Here we tested the hypothesis that YF1, a 56-nucleotide Y RNA fragment, could alleviate cardiomyocyte hypertrophy,...

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Detalles Bibliográficos
Autores principales: Huang, Feng, Na, Na, Ijichi, Takeshi, Wu, Xiaokang, Miyamoto, Kazutaka, Ciullo, Alessandra, Tran, My, Li, Liang, Ibrahim, Ahmed, Marbán, Eduardo, de Couto, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141670/
https://www.ncbi.nlm.nih.gov/pubmed/34094713
http://dx.doi.org/10.1016/j.omtn.2021.04.014

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