Cargando…

β-Asarone Ameliorates β-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway

Accumulation of β-amyloid (Aβ) causes oxidative stress, which is the major pathological mechanism in Alzheimer’s disease (AD). β-asarone could reduce Aβ-induced oxidative stress and neuronal damage, but the molecular mechanism remains elusive. In this study, we used an Aβ-stimulated PC12 cell model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Miaomiao, Zhang, Lijuan, AI, Di, Wu, Hongyun, Peng, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141729/ https://www.ncbi.nlm.nih.gov/pubmed/34040526 http://dx.doi.org/10.3389/fphar.2021.659955

Ejemplares similares

β-Asarone Attenuates Aβ-Induced Neuronal Damage in PC12 Cells Overexpressing APPswe by Restoring Autophagic Flux
por: Li, Zhenwan, et al.
Publicado: (2021)

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease
por: Wang, Nanbu, et al.
Publicado: (2020)

Effect of β-asarone in normal and β-amyloid-induced Alzheimeric rats
por: Saki, Golshid, et al.
Publicado: (2020)

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells
por: Wang, Lai, et al.
Publicado: (2018)

Preclinical evidence and possible mechanisms of β-asarone for rats and mice with Alzheimer’s disease: A systematic review and meta-analysis
por: Du, Xin-Yuan, et al.
Publicado: (2022)

Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β
por: Fan, Xiaoye, et al.
Publicado: (2018)

The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer's Disease
por: Wang, Nanbu, et al.
Publicado: (2021)

Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells
por: Hong, Seung-Young, et al.
Publicado: (2012)

Fate of β-asarone in Ayurvedic Sodhana process of Vacha
por: Gholkar, Manasi S., et al.
Publicado: (2013)

Hepatotoxic potential of asarones: in vitro evaluation of hepatotoxicity and quantitative determination in herbal products
por: Patel, Dhavalkumar N., et al.
Publicado: (2015)

α-Asarone Attenuates Osteoclastogenesis and Prevents Against Oestrogen-Deficiency Induced Osteoporosis
por: Tian, Hao, et al.
Publicado: (2022)

Nitro Derivatives of Naturally Occurring β-Asarone and Their Anticancer Activity
por: Shenvi, Suvarna, et al.
Publicado: (2014)

Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticity
por: Anastasio, Thomas J.
Publicado: (2014)

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway
por: Tan, Ji Wei, et al.
Publicado: (2016)

Synergetic effect of β-asarone and cannabidiol against Aβ aggregation in vitro and in vivo
por: Duan, Fangyuan, et al.
Publicado: (2023)

Curcumin Protects β-Lactoglobulin Fibril Formation and Fibril-Induced Neurotoxicity in PC12Cells
por: Mazaheri, Mansooreh, et al.
Publicado: (2015)

The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells
por: Jesky, Robert, et al.
Publicado: (2016)

Oral Administration of α-Asarone Promotes Functional Recovery in Rats With Spinal Cord Injury
por: Jo, Min-Jae, et al.
Publicado: (2018)

Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β(1–42) Oligomers
por: Wang, Li-Sha, et al.
Publicado: (2019)

Ameliorating the Developmental Neurotoxicity of Chlorpyrifos: A Mechanisms-Based Approach in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2007)

β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer
por: Tao, Heyun, et al.
Publicado: (2020)

Corrigendum: Oral Administration of α-Asarone Promotes Functional Recovery in Rats With Spinal Cord Injury
por: Jo, Min-Jae, et al.
Publicado: (2018)

Adlay hull extracts attenuate β-amyloid-induced neurotoxicity and oxidative stress in PC12 cells through antioxidative, anti-inflammatory, and antiapoptotic activities
por: Tsay, Gregory J., et al.
Publicado: (2021)

Dec1 Deficiency Ameliorates Pulmonary Fibrosis Through the PI3K/AKT/GSK-3β/β-Catenin Integrated Signaling Pathway
por: Hu, Xingxing, et al.
Publicado: (2022)

Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK
por: Li, Li, et al.
Publicado: (2013)

β-Asarone Protects PC12 Cells Against Hypoxia-Induced Injury Via Negatively Regulating RPPH1/MiR-542-3p/DEDD2 Axis
por: Yang, Fan, et al.
Publicado: (2022)

A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
por: Han, Dongjian, et al.
Publicado: (2022)

Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells
por: Murata, Tomiyasu, et al.
Publicado: (2018)

Salidroside protects PC-12 cells against amyloid β-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways
por: Liao, Zheng-Luan, et al.
Publicado: (2019)

β-Asarone Rescues Pb-Induced Impairments of Spatial Memory and Synaptogenesis in Rats
por: Yang, Qian-Qian, et al.
Publicado: (2016)

Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders
por: Balakrishnan, Rengasamy, et al.
Publicado: (2022)

Explore the Mechanism of β-Asarone on Improving Cognitive Dysfunction in Rats with Diabetic Encephalopathy
por: Cai, Jingwen, et al.
Publicado: (2022)

Neuroprotective Effects and Mechanism of β-Asarone against Aβ1–42-Induced Injury in Astrocytes
por: Yang, Yuanxiao, et al.
Publicado: (2017)

Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction via AKT/GSK3β/FYN-Mediated NRF2 Activation
por: Xuan, Yue, et al.
Publicado: (2022)

Erratum to “Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK”
por: Li, Li, et al.
Publicado: (2014)

Retracted: Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK
por: Evidence-Based Complementary and Alternative Medicine,
Publicado: (2019)

Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells
por: AI, ZHIBING, et al.
Publicado: (2015)

Identification of both GABA(A) receptors and voltage-activated Na(+) channels as molecular targets of anticonvulsant α-asarone
por: Wang, Ze-Jun, et al.
Publicado: (2014)

The Protective Effect of DiDang Tang Against AlCl(3)-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway
por: Lu, Jing, et al.
Publicado: (2020)

Hederagenin Protects PC12 Cells Against Corticosterone-Induced Injury by the Activation of the PI3K/AKT Pathway
por: Lin, Ruohong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e6r06l9pbm10f9c5q6dd249oi3