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Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse OCT1 suggested an OCT1-mediated efflux of IBC....

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Detalles Bibliográficos
Autores principales:	Jensen, Ole, Matthaei, Johannes, Klemp, Henry G., Meyer, Marleen J., Brockmöller, Jürgen, Tzvetkov, Mladen V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141810/ https://www.ncbi.nlm.nih.gov/pubmed/34040533 http://dx.doi.org/10.3389/fphar.2021.674559

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