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A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review
A well-documented method and experimental design are essential to ensure the reproducibility and reliability in animal research. Experimental studies using exercise programs in animal models have experienced an exponential increase in the last decades. Complete reporting of forced wheel and treadmil...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141847/ https://www.ncbi.nlm.nih.gov/pubmed/34040580 http://dx.doi.org/10.3389/fendo.2021.638261 |
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author | Garrigos, Daniel Martínez-Morga, Marta Toval, Angel Kutsenko, Yevheniy Barreda, Alberto Do Couto, Bruno Ribeiro Navarro-Mateu, Fernando Ferran, José Luis |
author_facet | Garrigos, Daniel Martínez-Morga, Marta Toval, Angel Kutsenko, Yevheniy Barreda, Alberto Do Couto, Bruno Ribeiro Navarro-Mateu, Fernando Ferran, José Luis |
author_sort | Garrigos, Daniel |
collection | PubMed |
description | A well-documented method and experimental design are essential to ensure the reproducibility and reliability in animal research. Experimental studies using exercise programs in animal models have experienced an exponential increase in the last decades. Complete reporting of forced wheel and treadmill exercise protocols would help to ensure the reproducibility of training programs. However, forced exercise programs are characterized by a poorly detailed methodology. Also, current guidelines do not cover the minimum data that must be included in published works to reproduce training programs. For this reason, we have carried out a systematic review to determine the reproducibility of training programs and experimental designs of published research in rodents using a forced wheel system. Having determined that most of the studies were not detailed enough to be reproducible, we have suggested guidelines for animal research using FORCED exercise wheels, which could also be applicable to any form of forced exercise. |
format | Online Article Text |
id | pubmed-8141847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81418472021-05-25 A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review Garrigos, Daniel Martínez-Morga, Marta Toval, Angel Kutsenko, Yevheniy Barreda, Alberto Do Couto, Bruno Ribeiro Navarro-Mateu, Fernando Ferran, José Luis Front Endocrinol (Lausanne) Endocrinology A well-documented method and experimental design are essential to ensure the reproducibility and reliability in animal research. Experimental studies using exercise programs in animal models have experienced an exponential increase in the last decades. Complete reporting of forced wheel and treadmill exercise protocols would help to ensure the reproducibility of training programs. However, forced exercise programs are characterized by a poorly detailed methodology. Also, current guidelines do not cover the minimum data that must be included in published works to reproduce training programs. For this reason, we have carried out a systematic review to determine the reproducibility of training programs and experimental designs of published research in rodents using a forced wheel system. Having determined that most of the studies were not detailed enough to be reproducible, we have suggested guidelines for animal research using FORCED exercise wheels, which could also be applicable to any form of forced exercise. Frontiers Media S.A. 2021-05-10 /pmc/articles/PMC8141847/ /pubmed/34040580 http://dx.doi.org/10.3389/fendo.2021.638261 Text en Copyright © 2021 Garrigos, Martínez-Morga, Toval, Kutsenko, Barreda, Do Couto, Navarro-Mateu and Ferran https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Garrigos, Daniel Martínez-Morga, Marta Toval, Angel Kutsenko, Yevheniy Barreda, Alberto Do Couto, Bruno Ribeiro Navarro-Mateu, Fernando Ferran, José Luis A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review |
title | A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review |
title_full | A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review |
title_fullStr | A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review |
title_full_unstemmed | A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review |
title_short | A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review |
title_sort | handful of details to ensure the experimental reproducibility on the forced running wheel in rodents: a systematic review |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141847/ https://www.ncbi.nlm.nih.gov/pubmed/34040580 http://dx.doi.org/10.3389/fendo.2021.638261 |
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