Cargando…
Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease
BACKGROUND: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. METHODS: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pat...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142073/ https://www.ncbi.nlm.nih.gov/pubmed/34030677 http://dx.doi.org/10.1186/s12920-021-00970-7 |
| _version_ | 1783696502387900416 |
|---|---|
| author | Bickler, Stephen W. Cauvi, David M. Fisch, Kathleen M. Prieto, James M. Sykes, Alicia G. Thangarajah, Hariharan Lazar, David A. Ignacio, Romeo C. Gerstmann, Dale R. Ryan, Allen F. Bickler, Philip E. De Maio, Antonio |
| author_facet | Bickler, Stephen W. Cauvi, David M. Fisch, Kathleen M. Prieto, James M. Sykes, Alicia G. Thangarajah, Hariharan Lazar, David A. Ignacio, Romeo C. Gerstmann, Dale R. Ryan, Allen F. Bickler, Philip E. De Maio, Antonio |
| author_sort | Bickler, Stephen W. |
| collection | PubMed |
| description | BACKGROUND: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. METHODS: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2. RESULTS: Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. CONCLUSIONS: Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-021-00970-7. |
| format | Online Article Text |
| id | pubmed-8142073 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81420732021-05-24 Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease Bickler, Stephen W. Cauvi, David M. Fisch, Kathleen M. Prieto, James M. Sykes, Alicia G. Thangarajah, Hariharan Lazar, David A. Ignacio, Romeo C. Gerstmann, Dale R. Ryan, Allen F. Bickler, Philip E. De Maio, Antonio BMC Med Genomics Research Article BACKGROUND: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. METHODS: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2. RESULTS: Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. CONCLUSIONS: Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-021-00970-7. BioMed Central 2021-05-24 /pmc/articles/PMC8142073/ /pubmed/34030677 http://dx.doi.org/10.1186/s12920-021-00970-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| spellingShingle | Research Article Bickler, Stephen W. Cauvi, David M. Fisch, Kathleen M. Prieto, James M. Sykes, Alicia G. Thangarajah, Hariharan Lazar, David A. Ignacio, Romeo C. Gerstmann, Dale R. Ryan, Allen F. Bickler, Philip E. De Maio, Antonio Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |
| title | Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |
| title_full | Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |
| title_fullStr | Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |
| title_full_unstemmed | Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |
| title_short | Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |
| title_sort | extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ace2, the receptor for sars-cov-2: implications for the epidemiology of covid-19 disease |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142073/ https://www.ncbi.nlm.nih.gov/pubmed/34030677 http://dx.doi.org/10.1186/s12920-021-00970-7 |
| work_keys_str_mv | AT bicklerstephenw extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT cauvidavidm extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT fischkathleenm extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT prietojamesm extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT sykesaliciag extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT thangarajahhariharan extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT lazardavida extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT ignacioromeoc extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT gerstmanndaler extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT ryanallenf extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT bicklerphilipe extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease AT demaioantonio extremesofageareassociatedwithdifferencesintheexpressionofselectedpatternrecognitionreceptorgenesandace2thereceptorforsarscov2implicationsfortheepidemiologyofcovid19disease |