Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease

BACKGROUND: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. METHODS: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pat...

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Detalles Bibliográficos
Autores principales: Bickler, Stephen W., Cauvi, David M., Fisch, Kathleen M., Prieto, James M., Sykes, Alicia G., Thangarajah, Hariharan, Lazar, David A., Ignacio, Romeo C., Gerstmann, Dale R., Ryan, Allen F., Bickler, Philip E., De Maio, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142073/
https://www.ncbi.nlm.nih.gov/pubmed/34030677
http://dx.doi.org/10.1186/s12920-021-00970-7

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