Cargando…

Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells

The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction, the quinols—if not conjugated—re-oxidizes sponta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chhour, Monivan, Perio, Pierre, Gayon, Regis, Ternet-Fontebasso, Hélène, Ferry, Gilles, Nepveu, Françoise, Boutin, Jean A., Sudor, Jan, Reybier, Karine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142080/ https://www.ncbi.nlm.nih.gov/pubmed/34040527 http://dx.doi.org/10.3389/fphar.2021.660641

Ejemplares similares

Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates
por: Chhour, Monivan, et al.
Publicado: (2019)

Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives
por: Cassagnes, Laure-Estelle, et al.
Publicado: (2017)

LUCS (Light-Up Cell System), a universal high throughput assay for homeostasis evaluation in live cells
por: Derick, Sylvain, et al.
Publicado: (2017)

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs
por: Runge-Morris, Melissa, et al.
Publicado: (2009)

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases
por: Fujiwara, Ryoichi, et al.
Publicado: (2016)

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
por: Grant, Delores J., et al.
Publicado: (2017)

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
por: Zhou, Lucas, et al.
Publicado: (2023)

Effects of Dietary Components on Testosterone Metabolism via UDP-Glucuronosyltransferase
por: Jenkinson, Carl, et al.
Publicado: (2013)

The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase
por: Jiang, Li-Peng, et al.
Publicado: (2014)

Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases
por: Shan, Lina, et al.
Publicado: (2014)

Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
por: Allain, Eric P., et al.
Publicado: (2020)

Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis
por: Zeng, Wanying, et al.
Publicado: (2022)

Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview
por: Guillemette, Chantal, et al.
Publicado: (2004)

Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term
por: Reimers, Arne, et al.
Publicado: (2010)

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication
por: Ouzzine, Mohamed, et al.
Publicado: (2014)

Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk
por: Wang, J, et al.
Publicado: (2013)

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics
por: Rouleau, Michèle, et al.
Publicado: (2017)

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children
por: Neumann, Elizabeth, et al.
Publicado: (2016)

Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases
por: Pan, Yiou, et al.
Publicado: (2018)

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice
por: Böhmdorfer, Michaela, et al.
Publicado: (2017)

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)
por: Zhang, Xu-Xin, et al.
Publicado: (2017)

Characterization of UDP-Glucuronosyltransferases and the Potential Contribution to Nicotine Tolerance in Myzus persicae
por: Pan, Yiou, et al.
Publicado: (2019)

Machine learning and structure-based modeling for the prediction of UDP-glucuronosyltransferase inhibition
por: Dudas, Balint, et al.
Publicado: (2022)

Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer
por: Wang, Min, et al.
Publicado: (2013)

Anti-Cancer Drugs Elicit Re-Expression of UDP-Glucuronosyltransferases in Melanoma Cells
por: Dellinger, Ryan W., et al.
Publicado: (2012)

Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
por: Greer, Aleksandra K., et al.
Publicado: (2014)

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development
por: YABUSAKI, Risa, et al.
Publicado: (2015)

Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity
por: You, Byoung Hoon, et al.
Publicado: (2018)

UDP‐glucuronosyltransferase polymorphisms affect diethylnitrosamine‐induced carcinogenesis in humanized transgenic mice
por: Landerer, Steffen, et al.
Publicado: (2020)

Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis
por: Flynn, Alexander F., et al.
Publicado: (2019)

The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases
por: Jarrar, Yazun, et al.
Publicado: (2021)

Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences
por: Chen, Juan, et al.
Publicado: (2023)

Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases
por: Zhang, Nan, et al.
Publicado: (2015)

Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP-Glucuronosyltransferases
por: Jeong, Hyesoo, et al.
Publicado: (2018)

Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Whole-exome Sequencing of Prostate Cancer in Sardinian Identify Recurrent UDP-glucuronosyltransferase Amplifications
por: Zeng, Tiansheng, et al.
Publicado: (2021)

Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
por: Sheng, Yun, et al.
Publicado: (2021)

Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)
por: Kondo, Mitsuki, et al.
Publicado: (2022)

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
por: Fretzayas, Andrew, et al.
Publicado: (2011)

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
por: Illingworth, NA, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_c2jvtsv01668eflfp9crca9agq