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Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism Patients With Pre-Existing Versus New-Onset Atrial Fibrillation
Pulmonary embolism (PE) patients have an increased prevalence and incidence of atrial fibrillation (AF). Because comorbid AF increases risk of morbidity and mortality, we sought to investigate the role of thrombo-inflammatory biomarkers in risk stratifying patients who experience an acute PE episode...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142239/ https://www.ncbi.nlm.nih.gov/pubmed/34013785 http://dx.doi.org/10.1177/10760296211014964 |
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author | Patel, Dimpi Darki, Amir Hoppensteadt, Debra Darwish, Iman Syed, Mushabbar Brailovsky, Yevgeniy Fareed, Jawed |
author_facet | Patel, Dimpi Darki, Amir Hoppensteadt, Debra Darwish, Iman Syed, Mushabbar Brailovsky, Yevgeniy Fareed, Jawed |
author_sort | Patel, Dimpi |
collection | PubMed |
description | Pulmonary embolism (PE) patients have an increased prevalence and incidence of atrial fibrillation (AF). Because comorbid AF increases risk of morbidity and mortality, we sought to investigate the role of thrombo-inflammatory biomarkers in risk stratifying patients who experience an acute PE episode. Study participants were enrolled from a Pulmonary Embolism Response Team (PERT) registry between March 2016 and March 2019 at Loyola University Medical Center and Gottlieb Memorial Hospital. This cohort was divided into 3 groups: PE patients with a prior diagnosis of AF (n = 8), PE patients with a subsequent diagnosis of AF (n = 11), and PE patients who do not develop AF (n = 71). D-dimer, CRP, PAI-1, TAFIa, FXIIIa, A2A, MP, and TFPI were profiled using the ELISA method. All biomarkers were significantly different between controls and PE patients (P < 0.05). Furthermore, TFPI was significantly elevated in PE patients who subsequently developed AF compared to PE patients who did not develop AF (157.7 ± 19.0 ng/mL vs. 129.0 ± 9.3 ng/mL, P = 0.0386). This study suggests that thrombo-inflammatory biomarkers may be helpful in indicating an acute PE episode. Also, elevated TFPI levels may be associated with an increased risk of developing AF after a PE. |
format | Online Article Text |
id | pubmed-8142239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-81422392021-06-04 Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism Patients With Pre-Existing Versus New-Onset Atrial Fibrillation Patel, Dimpi Darki, Amir Hoppensteadt, Debra Darwish, Iman Syed, Mushabbar Brailovsky, Yevgeniy Fareed, Jawed Clin Appl Thromb Hemost Original Article Pulmonary embolism (PE) patients have an increased prevalence and incidence of atrial fibrillation (AF). Because comorbid AF increases risk of morbidity and mortality, we sought to investigate the role of thrombo-inflammatory biomarkers in risk stratifying patients who experience an acute PE episode. Study participants were enrolled from a Pulmonary Embolism Response Team (PERT) registry between March 2016 and March 2019 at Loyola University Medical Center and Gottlieb Memorial Hospital. This cohort was divided into 3 groups: PE patients with a prior diagnosis of AF (n = 8), PE patients with a subsequent diagnosis of AF (n = 11), and PE patients who do not develop AF (n = 71). D-dimer, CRP, PAI-1, TAFIa, FXIIIa, A2A, MP, and TFPI were profiled using the ELISA method. All biomarkers were significantly different between controls and PE patients (P < 0.05). Furthermore, TFPI was significantly elevated in PE patients who subsequently developed AF compared to PE patients who did not develop AF (157.7 ± 19.0 ng/mL vs. 129.0 ± 9.3 ng/mL, P = 0.0386). This study suggests that thrombo-inflammatory biomarkers may be helpful in indicating an acute PE episode. Also, elevated TFPI levels may be associated with an increased risk of developing AF after a PE. SAGE Publications 2021-05-20 /pmc/articles/PMC8142239/ /pubmed/34013785 http://dx.doi.org/10.1177/10760296211014964 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Patel, Dimpi Darki, Amir Hoppensteadt, Debra Darwish, Iman Syed, Mushabbar Brailovsky, Yevgeniy Fareed, Jawed Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism Patients With Pre-Existing Versus New-Onset Atrial Fibrillation |
title | Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism
Patients With Pre-Existing Versus New-Onset Atrial Fibrillation |
title_full | Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism
Patients With Pre-Existing Versus New-Onset Atrial Fibrillation |
title_fullStr | Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism
Patients With Pre-Existing Versus New-Onset Atrial Fibrillation |
title_full_unstemmed | Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism
Patients With Pre-Existing Versus New-Onset Atrial Fibrillation |
title_short | Biomarkers of Thrombo-Inflammatory Responses in Pulmonary Embolism
Patients With Pre-Existing Versus New-Onset Atrial Fibrillation |
title_sort | biomarkers of thrombo-inflammatory responses in pulmonary embolism
patients with pre-existing versus new-onset atrial fibrillation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142239/ https://www.ncbi.nlm.nih.gov/pubmed/34013785 http://dx.doi.org/10.1177/10760296211014964 |
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