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Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder

OBJECTIVES: Surgical procedures targeting the anterior limb of the internal capsule (aLIC) can be effective in patients with selected treatment-refractory obsessive-compulsive disorder (OCD). The aLIC consists of white-matter tracts connecting cortical and subcortical structures and show a topograph...

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Autores principales: Zhang, Chencheng, Kim, Seung-Goo, Li, Jun, Zhang, Yingying, Lv, Qiming, Zeljic, Kristina, Gong, Hengfen, Wei, Hongjiang, Liu, Wenjuan, Sun, Bomin, Wang, Zheng, Voon, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142462/
https://www.ncbi.nlm.nih.gov/pubmed/33461976
http://dx.doi.org/10.1136/jnnp-2020-323062
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author Zhang, Chencheng
Kim, Seung-Goo
Li, Jun
Zhang, Yingying
Lv, Qiming
Zeljic, Kristina
Gong, Hengfen
Wei, Hongjiang
Liu, Wenjuan
Sun, Bomin
Wang, Zheng
Voon, Valerie
author_facet Zhang, Chencheng
Kim, Seung-Goo
Li, Jun
Zhang, Yingying
Lv, Qiming
Zeljic, Kristina
Gong, Hengfen
Wei, Hongjiang
Liu, Wenjuan
Sun, Bomin
Wang, Zheng
Voon, Valerie
author_sort Zhang, Chencheng
collection PubMed
description OBJECTIVES: Surgical procedures targeting the anterior limb of the internal capsule (aLIC) can be effective in patients with selected treatment-refractory obsessive-compulsive disorder (OCD). The aLIC consists of white-matter tracts connecting cortical and subcortical structures and show a topographical organisation. Here we assess how aLIC streamlines are affected in OCD compared with healthy controls (HCs) and which streamlines are related with post-capsulotomy improvement. METHODS: Diffusion-weighted MRI was used to compare white-matter microstructure via the aLIC between patients with OCD (n=100, 40 women, mean of age 31.8 years) and HCs (n=88, 39 women, mean of age 29.6 years). For each individual, the fractional anisotropy (FA) and streamline counts were calculated for each white-matter fibre bundle connecting a functionally defined prefrontal and subcortical region. Correlations between tractography measures and pre-capsulotomy and post-capsulotomy clinical outcomes (in obsessive-compulsive, anxiety and depression scores 6 months after surgery) were assessed in 41 patients with OCD. RESULTS: Hierarchical clustering dendrograms show an aLIC organisation clustering lateral and dissociating ventral and dorsal prefrontal–thalamic streamlines, findings highly relevant to surgical targeting. Compared with HCs, patients with OCD had lower aLIC FA across multiple prefrontal cortical–subcortical regions (p<0.0073, false discovery rate-adjusted). Greater streamline counts of the dorsolateral prefrontal–thalamic tracts in patients with OCD predicted greater post-capsulotomy obsessive-compulsive improvement (p=0.016). In contrast, greater counts of the dorsal cingulate–thalamic streamlines predicted surgical outcomes mediated by depressive and anxiety improvements. CONCLUSIONS: These findings shed light on the critical role of the aLIC in OCD and may potentially contribute towards precision targeting to optimise outcomes in OCD.
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spelling pubmed-81424622021-06-07 Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder Zhang, Chencheng Kim, Seung-Goo Li, Jun Zhang, Yingying Lv, Qiming Zeljic, Kristina Gong, Hengfen Wei, Hongjiang Liu, Wenjuan Sun, Bomin Wang, Zheng Voon, Valerie J Neurol Neurosurg Psychiatry Neurosurgery OBJECTIVES: Surgical procedures targeting the anterior limb of the internal capsule (aLIC) can be effective in patients with selected treatment-refractory obsessive-compulsive disorder (OCD). The aLIC consists of white-matter tracts connecting cortical and subcortical structures and show a topographical organisation. Here we assess how aLIC streamlines are affected in OCD compared with healthy controls (HCs) and which streamlines are related with post-capsulotomy improvement. METHODS: Diffusion-weighted MRI was used to compare white-matter microstructure via the aLIC between patients with OCD (n=100, 40 women, mean of age 31.8 years) and HCs (n=88, 39 women, mean of age 29.6 years). For each individual, the fractional anisotropy (FA) and streamline counts were calculated for each white-matter fibre bundle connecting a functionally defined prefrontal and subcortical region. Correlations between tractography measures and pre-capsulotomy and post-capsulotomy clinical outcomes (in obsessive-compulsive, anxiety and depression scores 6 months after surgery) were assessed in 41 patients with OCD. RESULTS: Hierarchical clustering dendrograms show an aLIC organisation clustering lateral and dissociating ventral and dorsal prefrontal–thalamic streamlines, findings highly relevant to surgical targeting. Compared with HCs, patients with OCD had lower aLIC FA across multiple prefrontal cortical–subcortical regions (p<0.0073, false discovery rate-adjusted). Greater streamline counts of the dorsolateral prefrontal–thalamic tracts in patients with OCD predicted greater post-capsulotomy obsessive-compulsive improvement (p=0.016). In contrast, greater counts of the dorsal cingulate–thalamic streamlines predicted surgical outcomes mediated by depressive and anxiety improvements. CONCLUSIONS: These findings shed light on the critical role of the aLIC in OCD and may potentially contribute towards precision targeting to optimise outcomes in OCD. BMJ Publishing Group 2021-06 2021-01-18 /pmc/articles/PMC8142462/ /pubmed/33461976 http://dx.doi.org/10.1136/jnnp-2020-323062 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Neurosurgery
Zhang, Chencheng
Kim, Seung-Goo
Li, Jun
Zhang, Yingying
Lv, Qiming
Zeljic, Kristina
Gong, Hengfen
Wei, Hongjiang
Liu, Wenjuan
Sun, Bomin
Wang, Zheng
Voon, Valerie
Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
title Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
title_full Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
title_fullStr Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
title_full_unstemmed Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
title_short Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
title_sort anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder
topic Neurosurgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142462/
https://www.ncbi.nlm.nih.gov/pubmed/33461976
http://dx.doi.org/10.1136/jnnp-2020-323062
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