Cargando…

Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice

BACKGROUND: The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? We hypothesized that CBD would produce a dose-dependent reduction in brain activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadaka, Aymen H., Ozuna, Ana G., Ortiz, Richard J., Kulkarni, Praveen, Johnson, Clare T., Bradshaw, Heather B., Cushing, Bruce S., Li, Ai-Ling, Hohmann, Andrea G., Ferris, Craig F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142641/ https://www.ncbi.nlm.nih.gov/pubmed/34030718 http://dx.doi.org/10.1186/s12967-021-02891-6

Ejemplares similares

Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats
por: Cai, Xuezhu, et al.
Publicado: (2021)

Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study
por: Sadaka, Aymen H., et al.
Publicado: (2023)

Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats
por: Cai, Xuezhu, et al.
Publicado: (2020)

Studies on the Q175 Knock-in Model of Huntington’s Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction
por: Ferris, Craig F., et al.
Publicado: (2014)

Dose‐dependent effects of esketamine on brain activity in awake mice: A BOLD phMRI study
por: Kawazoe, Kyrsten, et al.
Publicado: (2022)

Applications in Awake Animal Magnetic Resonance Imaging
por: Ferris, Craig F.
Publicado: (2022)

The Serotonin Receptor 6 Antagonist Idalopirdine and Acetylcholinesterase Inhibitor Donepezil Have Synergistic Effects on Brain Activity—A Functional MRI Study in the Awake Rat
por: Ferris, Craig F., et al.
Publicado: (2017)

Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats
por: Ferris, Craig F., et al.
Publicado: (2015)

BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone
por: Moore, Kelsey, et al.
Publicado: (2016)

The pharmacology and therapeutic role of cannabidiol in diabetes
por: Zhang, Jin, et al.
Publicado: (2023)

Identifying the integrated neural networks involved in capsaicin-induced pain using fMRI in awake TRPV1 knockout and wild-type rats
por: Yee, Jason R., et al.
Publicado: (2015)

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats
por: Brems, Brittany M., et al.
Publicado: (2023)

Cannabidiol but not cannabidiolic acid reduces behavioural sensitisation to methamphetamine in rats, at pharmacologically effective doses
por: Umpierrez, Laísa S., et al.
Publicado: (2022)

Cannabis Contaminants Limit Pharmacological Use of Cannabidiol
por: Montoya, Zackary, et al.
Publicado: (2020)

Δ(9)-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure
por: Miller, Sally, et al.
Publicado: (2018)

Effects of (−)‐MBP, a novel 5‐HT(2C) agonist and 5‐HT(2A/2B) antagonist/inverse agonist on brain activity: A phMRI study on awake mice
por: Sathe, Preeti K., et al.
Publicado: (2023)

Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
por: Mlost, Jakub, et al.
Publicado: (2020)

Parasitic pharmacology: A plausible mechanism of action for cannabidiol
por: Groeneveld, Geert Jan, et al.
Publicado: (2019)

Unique spatiotemporal fMRI dynamics in the awake mouse brain
por: Gutierrez-Barragan, Daniel, et al.
Publicado: (2022)

Dataset on a 173 region awake resting state quantitative cerebral blood volume rat brain atlas and regional changes to cerebral blood volume under isoflurane anesthetization and CO(2) challenge
por: Gharagouzloo, Codi A., et al.
Publicado: (2018)

The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets
por: Vitale, Rosa Maria, et al.
Publicado: (2021)

Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2021)

Development, Characterization and Pharmacological Evaluation of Cannabidiol-Loaded Long Circulating Niosomes
por: Gugleva, Viliana, et al.
Publicado: (2023)

Cannabidiol’s Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review
por: Henry, Nicholas, et al.
Publicado: (2022)

Alterations in brain neurocircuitry following treatment with the chemotherapeutic agent paclitaxel in rats
por: Ferris, Craig F., et al.
Publicado: (2019)

Cannabidiol: A Brief Review of Its Therapeutic and Pharmacologic Efficacy in the Management of Joint Disease
por: Gusho, Charles A, et al.
Publicado: (2020)

Pharmacological Evaluation of Newly Synthesized Cannabidiol Derivates on H9c2 Cells
por: Szőke, Kitti, et al.
Publicado: (2023)

Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D
por: Leishman, Emma, et al.
Publicado: (2018)

Abnormal Cannabidiol Affects Production of Pro-Inflammatory Mediators and Astrocyte Wound Closure in Primary Astrocytic-Microglial Cocultures
por: Cardinal von Widdern, Julian, et al.
Publicado: (2020)

Wide-Awake Hand Surgery Has Its Benefits: A Study of 1,011 Patients
por: McKnight, Kelly N., et al.
Publicado: (2022)

Awake prone positioning
por: McNicholas, Bairbre A., et al.
Publicado: (2022)

Functional magnetic resonance imaging in awake transgenic fragile X rats: evidence of dysregulation in reward processing in the mesolimbic/habenular neural circuit
por: Kenkel, W M, et al.
Publicado: (2016)

The antimicrobial potential of cannabidiol
por: Blaskovich, Mark A. T., et al.
Publicado: (2021)

Pharmacological Evaluation of Signals of Disproportionality Reporting Related to Adverse Reactions to Antiepileptic Cannabidiol in VigiBase
por: Calapai, Fabrizio, et al.
Publicado: (2023)

Evaluating blood–brain barrier permeability in a rat model of type 2 diabetes
por: Qiao, Ju, et al.
Publicado: (2020)

Awake craniotomy versus piloting an aircraft: What medicine and aviation can learn from one another?
por: Khurana, Vini G., et al.
Publicado: (2019)

Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function
por: Abbotts, Kieran Shay Struebin, et al.
Publicado: (2022)

Using multimodal MRI to investigate alterations in brain structure and function in the BBZDR/Wor rat model of type 2 diabetes
por: Lawson, Christopher M., et al.
Publicado: (2020)

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?
por: Rocha, Luisa, et al.
Publicado: (2020)

Chronic Adolescent Δ(9)-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment
por: Murphy, Michelle, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jk4dttdk06rfv5s98krgp8km3r