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Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection

Multisystem inflammatory syndrome in adults (MIS-A) came to attention back in June 2020, when the United States Center for Disease Control and Prevention (CDC) received initial reports regarding patients who had presented delayed and multisystem involvement of the disease, with clinical course resem...

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Autores principales: Ahmad, Faran, Ahmed, Arslan, Rajendraprasad, Sanu S., Loranger, Austin, Gupta, Sonia, Velagapudi, Manasa, Vivekanandan, Renuga, Nahas, Joseph A., Plambeck, Robert, Moore, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142712/
https://www.ncbi.nlm.nih.gov/pubmed/34044140
http://dx.doi.org/10.1016/j.ijid.2021.05.050
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author Ahmad, Faran
Ahmed, Arslan
Rajendraprasad, Sanu S.
Loranger, Austin
Gupta, Sonia
Velagapudi, Manasa
Vivekanandan, Renuga
Nahas, Joseph A.
Plambeck, Robert
Moore, Douglas
author_facet Ahmad, Faran
Ahmed, Arslan
Rajendraprasad, Sanu S.
Loranger, Austin
Gupta, Sonia
Velagapudi, Manasa
Vivekanandan, Renuga
Nahas, Joseph A.
Plambeck, Robert
Moore, Douglas
author_sort Ahmad, Faran
collection PubMed
description Multisystem inflammatory syndrome in adults (MIS-A) came to attention back in June 2020, when the United States Center for Disease Control and Prevention (CDC) received initial reports regarding patients who had presented delayed and multisystem involvement of the disease, with clinical course resembling multisystem inflammatory syndrome in children (MIS-C). This study introduces a case of MIS-A, where the patient presented 3 weeks after initial COVID-19 exposure. His clinical course was consistent with the working definition of MIS-A as specified by the CDC. Aggressive supportive care in the intensive care unit, utilization of advanced heart failure devices, and immunomodulatory therapeutics (high-dose steroids, anakinra, intravenous immunoglobulin) led to clinical recovery. Management of MIS-A is a topic of ongoing research and needs more studies to elaborate on treatment modalities and clinical predictors.
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spelling pubmed-81427122021-05-25 Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection Ahmad, Faran Ahmed, Arslan Rajendraprasad, Sanu S. Loranger, Austin Gupta, Sonia Velagapudi, Manasa Vivekanandan, Renuga Nahas, Joseph A. Plambeck, Robert Moore, Douglas Int J Infect Dis Case Report Multisystem inflammatory syndrome in adults (MIS-A) came to attention back in June 2020, when the United States Center for Disease Control and Prevention (CDC) received initial reports regarding patients who had presented delayed and multisystem involvement of the disease, with clinical course resembling multisystem inflammatory syndrome in children (MIS-C). This study introduces a case of MIS-A, where the patient presented 3 weeks after initial COVID-19 exposure. His clinical course was consistent with the working definition of MIS-A as specified by the CDC. Aggressive supportive care in the intensive care unit, utilization of advanced heart failure devices, and immunomodulatory therapeutics (high-dose steroids, anakinra, intravenous immunoglobulin) led to clinical recovery. Management of MIS-A is a topic of ongoing research and needs more studies to elaborate on treatment modalities and clinical predictors. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-07 2021-05-24 /pmc/articles/PMC8142712/ /pubmed/34044140 http://dx.doi.org/10.1016/j.ijid.2021.05.050 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Ahmad, Faran
Ahmed, Arslan
Rajendraprasad, Sanu S.
Loranger, Austin
Gupta, Sonia
Velagapudi, Manasa
Vivekanandan, Renuga
Nahas, Joseph A.
Plambeck, Robert
Moore, Douglas
Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection
title Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection
title_full Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection
title_fullStr Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection
title_full_unstemmed Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection
title_short Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection
title_sort multisystem inflammatory syndrome in adults: a rare sequela of sars-cov-2 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142712/
https://www.ncbi.nlm.nih.gov/pubmed/34044140
http://dx.doi.org/10.1016/j.ijid.2021.05.050
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