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Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans

PURPOSE: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans. METHODS: Structure-function correlation was analyzed glob...

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Autores principales: Celebi, Ali Riza Cenk, Park, Elli A., Verticchio Vercellin, Alice Chandra, Tsikata, Edem, Lee, Ramon, Shieh, Eric, Antar, Hussein, Freeman, Madeline, Zhang, Jing, Que, Christian, Simavli, Huseyin, McClurkin, Michael, Guo, Rong, Elze, Tobias, de Boer, Johannes F., Chen, Teresa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142720/
https://www.ncbi.nlm.nih.gov/pubmed/34019635
http://dx.doi.org/10.1167/tvst.10.6.28
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author Celebi, Ali Riza Cenk
Park, Elli A.
Verticchio Vercellin, Alice Chandra
Tsikata, Edem
Lee, Ramon
Shieh, Eric
Antar, Hussein
Freeman, Madeline
Zhang, Jing
Que, Christian
Simavli, Huseyin
McClurkin, Michael
Guo, Rong
Elze, Tobias
de Boer, Johannes F.
Chen, Teresa C.
author_facet Celebi, Ali Riza Cenk
Park, Elli A.
Verticchio Vercellin, Alice Chandra
Tsikata, Edem
Lee, Ramon
Shieh, Eric
Antar, Hussein
Freeman, Madeline
Zhang, Jing
Que, Christian
Simavli, Huseyin
McClurkin, Michael
Guo, Rong
Elze, Tobias
de Boer, Johannes F.
Chen, Teresa C.
author_sort Celebi, Ali Riza Cenk
collection PubMed
description PURPOSE: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans. METHODS: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thickness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch's membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength. RESULTS: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statistically significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20). CONCLUSIONS: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness. TRANSLATIONAL RELEVANCE: This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma.
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spelling pubmed-81427202021-05-27 Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans Celebi, Ali Riza Cenk Park, Elli A. Verticchio Vercellin, Alice Chandra Tsikata, Edem Lee, Ramon Shieh, Eric Antar, Hussein Freeman, Madeline Zhang, Jing Que, Christian Simavli, Huseyin McClurkin, Michael Guo, Rong Elze, Tobias de Boer, Johannes F. Chen, Teresa C. Transl Vis Sci Technol Article PURPOSE: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans. METHODS: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thickness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch's membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength. RESULTS: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statistically significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20). CONCLUSIONS: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness. TRANSLATIONAL RELEVANCE: This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma. The Association for Research in Vision and Ophthalmology 2021-05-21 /pmc/articles/PMC8142720/ /pubmed/34019635 http://dx.doi.org/10.1167/tvst.10.6.28 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Article
Celebi, Ali Riza Cenk
Park, Elli A.
Verticchio Vercellin, Alice Chandra
Tsikata, Edem
Lee, Ramon
Shieh, Eric
Antar, Hussein
Freeman, Madeline
Zhang, Jing
Que, Christian
Simavli, Huseyin
McClurkin, Michael
Guo, Rong
Elze, Tobias
de Boer, Johannes F.
Chen, Teresa C.
Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans
title Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans
title_full Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans
title_fullStr Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans
title_full_unstemmed Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans
title_short Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans
title_sort structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142720/
https://www.ncbi.nlm.nih.gov/pubmed/34019635
http://dx.doi.org/10.1167/tvst.10.6.28
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