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Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression

INTRODUCTION: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an incr...

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Autores principales: Gatto, Antonio, Angelici, Serenella, Soligo, Marzia, Di Giuda, Daniela, Manni, Luigi, Curatola, Antonietta, Ferretti, Serena, Chiaretti, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142774/
https://www.ncbi.nlm.nih.gov/pubmed/33944821
http://dx.doi.org/10.23750/abm.v92iS1.10204
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author Gatto, Antonio
Angelici, Serenella
Soligo, Marzia
Di Giuda, Daniela
Manni, Luigi
Curatola, Antonietta
Ferretti, Serena
Chiaretti, Antonio
author_facet Gatto, Antonio
Angelici, Serenella
Soligo, Marzia
Di Giuda, Daniela
Manni, Luigi
Curatola, Antonietta
Ferretti, Serena
Chiaretti, Antonio
author_sort Gatto, Antonio
collection PubMed
description INTRODUCTION: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an increased production of cytokines have all been advocated as main factors in determining ischemic stroke. CASE REPORT: We report the case of an EBV-induced ischemic stroke in a caucasian 2-year-old female. The cerebrospinal fluid samples showed positivity of polymerase chain reaction for EBV infection, also confirmed by pharyngeal swab culture. Increased levels of interleukin 6 and interleukin 1β were also detected in the cerebrospinal fluid. DISCUSSION: EBV infection has been identified as an important cause of neurological involvement in children. Findings of increased levels of interleukin 6 and interleukin 1β in the cerebrospinal fluid of the child with EBV induced-ischemic stroke seems to validate the role of pro-inflammatory cytokines as crucial mediators of cerebral thrombus formation. CONCLUSIONS: We believe that this report can be useful to clarify some pathophysiological mechanisms related to ischemic stroke related to Epstein-Barr Virus (EBV) infection in children. (www.actabiomedica.it)
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spelling pubmed-81427742021-05-27 Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression Gatto, Antonio Angelici, Serenella Soligo, Marzia Di Giuda, Daniela Manni, Luigi Curatola, Antonietta Ferretti, Serena Chiaretti, Antonio Acta Biomed Case Report INTRODUCTION: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an increased production of cytokines have all been advocated as main factors in determining ischemic stroke. CASE REPORT: We report the case of an EBV-induced ischemic stroke in a caucasian 2-year-old female. The cerebrospinal fluid samples showed positivity of polymerase chain reaction for EBV infection, also confirmed by pharyngeal swab culture. Increased levels of interleukin 6 and interleukin 1β were also detected in the cerebrospinal fluid. DISCUSSION: EBV infection has been identified as an important cause of neurological involvement in children. Findings of increased levels of interleukin 6 and interleukin 1β in the cerebrospinal fluid of the child with EBV induced-ischemic stroke seems to validate the role of pro-inflammatory cytokines as crucial mediators of cerebral thrombus formation. CONCLUSIONS: We believe that this report can be useful to clarify some pathophysiological mechanisms related to ischemic stroke related to Epstein-Barr Virus (EBV) infection in children. (www.actabiomedica.it) Mattioli 1885 2021 2021-04-30 /pmc/articles/PMC8142774/ /pubmed/33944821 http://dx.doi.org/10.23750/abm.v92iS1.10204 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Case Report
Gatto, Antonio
Angelici, Serenella
Soligo, Marzia
Di Giuda, Daniela
Manni, Luigi
Curatola, Antonietta
Ferretti, Serena
Chiaretti, Antonio
Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
title Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
title_full Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
title_fullStr Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
title_full_unstemmed Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
title_short Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
title_sort pediatric cerebral stroke induced by epstein-barr virus infection: role of interleukin overexpression
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142774/
https://www.ncbi.nlm.nih.gov/pubmed/33944821
http://dx.doi.org/10.23750/abm.v92iS1.10204
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