Cargando…
Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression
INTRODUCTION: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an incr...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142774/ https://www.ncbi.nlm.nih.gov/pubmed/33944821 http://dx.doi.org/10.23750/abm.v92iS1.10204 |
_version_ | 1783696620302368768 |
---|---|
author | Gatto, Antonio Angelici, Serenella Soligo, Marzia Di Giuda, Daniela Manni, Luigi Curatola, Antonietta Ferretti, Serena Chiaretti, Antonio |
author_facet | Gatto, Antonio Angelici, Serenella Soligo, Marzia Di Giuda, Daniela Manni, Luigi Curatola, Antonietta Ferretti, Serena Chiaretti, Antonio |
author_sort | Gatto, Antonio |
collection | PubMed |
description | INTRODUCTION: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an increased production of cytokines have all been advocated as main factors in determining ischemic stroke. CASE REPORT: We report the case of an EBV-induced ischemic stroke in a caucasian 2-year-old female. The cerebrospinal fluid samples showed positivity of polymerase chain reaction for EBV infection, also confirmed by pharyngeal swab culture. Increased levels of interleukin 6 and interleukin 1β were also detected in the cerebrospinal fluid. DISCUSSION: EBV infection has been identified as an important cause of neurological involvement in children. Findings of increased levels of interleukin 6 and interleukin 1β in the cerebrospinal fluid of the child with EBV induced-ischemic stroke seems to validate the role of pro-inflammatory cytokines as crucial mediators of cerebral thrombus formation. CONCLUSIONS: We believe that this report can be useful to clarify some pathophysiological mechanisms related to ischemic stroke related to Epstein-Barr Virus (EBV) infection in children. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-8142774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-81427742021-05-27 Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression Gatto, Antonio Angelici, Serenella Soligo, Marzia Di Giuda, Daniela Manni, Luigi Curatola, Antonietta Ferretti, Serena Chiaretti, Antonio Acta Biomed Case Report INTRODUCTION: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an increased production of cytokines have all been advocated as main factors in determining ischemic stroke. CASE REPORT: We report the case of an EBV-induced ischemic stroke in a caucasian 2-year-old female. The cerebrospinal fluid samples showed positivity of polymerase chain reaction for EBV infection, also confirmed by pharyngeal swab culture. Increased levels of interleukin 6 and interleukin 1β were also detected in the cerebrospinal fluid. DISCUSSION: EBV infection has been identified as an important cause of neurological involvement in children. Findings of increased levels of interleukin 6 and interleukin 1β in the cerebrospinal fluid of the child with EBV induced-ischemic stroke seems to validate the role of pro-inflammatory cytokines as crucial mediators of cerebral thrombus formation. CONCLUSIONS: We believe that this report can be useful to clarify some pathophysiological mechanisms related to ischemic stroke related to Epstein-Barr Virus (EBV) infection in children. (www.actabiomedica.it) Mattioli 1885 2021 2021-04-30 /pmc/articles/PMC8142774/ /pubmed/33944821 http://dx.doi.org/10.23750/abm.v92iS1.10204 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Case Report Gatto, Antonio Angelici, Serenella Soligo, Marzia Di Giuda, Daniela Manni, Luigi Curatola, Antonietta Ferretti, Serena Chiaretti, Antonio Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression |
title | Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression |
title_full | Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression |
title_fullStr | Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression |
title_full_unstemmed | Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression |
title_short | Pediatric cerebral stroke induced by Epstein-Barr virus infection: role of interleukin overexpression |
title_sort | pediatric cerebral stroke induced by epstein-barr virus infection: role of interleukin overexpression |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142774/ https://www.ncbi.nlm.nih.gov/pubmed/33944821 http://dx.doi.org/10.23750/abm.v92iS1.10204 |
work_keys_str_mv | AT gattoantonio pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT angeliciserenella pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT soligomarzia pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT digiudadaniela pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT manniluigi pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT curatolaantonietta pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT ferrettiserena pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression AT chiarettiantonio pediatriccerebralstrokeinducedbyepsteinbarrvirusinfectionroleofinterleukinoverexpression |