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Iron Deficiency in Obesity and after Bariatric Surgery
Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duod...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142987/ https://www.ncbi.nlm.nih.gov/pubmed/33918997 http://dx.doi.org/10.3390/biom11050613 |
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author | Bjørklund, Geir Peana, Massimiliano Pivina, Lyudmila Dosa, Alexandru Aaseth, Jan Semenova, Yuliya Chirumbolo, Salvatore Medici, Serenella Dadar, Maryam Costea, Daniel-Ovidiu |
author_facet | Bjørklund, Geir Peana, Massimiliano Pivina, Lyudmila Dosa, Alexandru Aaseth, Jan Semenova, Yuliya Chirumbolo, Salvatore Medici, Serenella Dadar, Maryam Costea, Daniel-Ovidiu |
author_sort | Bjørklund, Geir |
collection | PubMed |
description | Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duodenal ferroportin expression, parallel to the increased concentrations of hepcidin. Obese subjects often get decreased inflammatory response after bariatric surgery, accompanied by decreased serum hepcidin and therefore improved iron absorption. Bariatric surgery can induce the mitigation or resolution of obesity-associated complications, such as hypertension, insulin resistance, diabetes mellitus, and hyperlipidemia, adjusting many parameters in the metabolism. However, gastric bypass surgery and sleeve gastrectomy can induce malabsorption and may accentuate ID. The present review explores the burden and characteristics of ID and anemia in obese patients after bariatric surgery, accounting for gastric bypass technique (Roux-en-Y gastric bypass—RYGB) and sleeve gastrectomy (SG). After bariatric surgery, obese subjects’ iron status should be monitored, and they should be motivated to use adequate and recommended iron supplementation. |
format | Online Article Text |
id | pubmed-8142987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81429872021-05-25 Iron Deficiency in Obesity and after Bariatric Surgery Bjørklund, Geir Peana, Massimiliano Pivina, Lyudmila Dosa, Alexandru Aaseth, Jan Semenova, Yuliya Chirumbolo, Salvatore Medici, Serenella Dadar, Maryam Costea, Daniel-Ovidiu Biomolecules Review Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duodenal ferroportin expression, parallel to the increased concentrations of hepcidin. Obese subjects often get decreased inflammatory response after bariatric surgery, accompanied by decreased serum hepcidin and therefore improved iron absorption. Bariatric surgery can induce the mitigation or resolution of obesity-associated complications, such as hypertension, insulin resistance, diabetes mellitus, and hyperlipidemia, adjusting many parameters in the metabolism. However, gastric bypass surgery and sleeve gastrectomy can induce malabsorption and may accentuate ID. The present review explores the burden and characteristics of ID and anemia in obese patients after bariatric surgery, accounting for gastric bypass technique (Roux-en-Y gastric bypass—RYGB) and sleeve gastrectomy (SG). After bariatric surgery, obese subjects’ iron status should be monitored, and they should be motivated to use adequate and recommended iron supplementation. MDPI 2021-04-21 /pmc/articles/PMC8142987/ /pubmed/33918997 http://dx.doi.org/10.3390/biom11050613 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bjørklund, Geir Peana, Massimiliano Pivina, Lyudmila Dosa, Alexandru Aaseth, Jan Semenova, Yuliya Chirumbolo, Salvatore Medici, Serenella Dadar, Maryam Costea, Daniel-Ovidiu Iron Deficiency in Obesity and after Bariatric Surgery |
title | Iron Deficiency in Obesity and after Bariatric Surgery |
title_full | Iron Deficiency in Obesity and after Bariatric Surgery |
title_fullStr | Iron Deficiency in Obesity and after Bariatric Surgery |
title_full_unstemmed | Iron Deficiency in Obesity and after Bariatric Surgery |
title_short | Iron Deficiency in Obesity and after Bariatric Surgery |
title_sort | iron deficiency in obesity and after bariatric surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142987/ https://www.ncbi.nlm.nih.gov/pubmed/33918997 http://dx.doi.org/10.3390/biom11050613 |
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