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Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study

Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an i...

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Autores principales: de la Rubia Ortí, Jose Enrique, Platero, Jose Luis, Benlloch, María, Franco-Martinez, Lorena, Tvarijonaviciute, Asta, Escribá-Alepuz, Jesús, Sancho-Castillo, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143085/
https://www.ncbi.nlm.nih.gov/pubmed/33919169
http://dx.doi.org/10.3390/biom11050617
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author de la Rubia Ortí, Jose Enrique
Platero, Jose Luis
Benlloch, María
Franco-Martinez, Lorena
Tvarijonaviciute, Asta
Escribá-Alepuz, Jesús
Sancho-Castillo, Sandra
author_facet de la Rubia Ortí, Jose Enrique
Platero, Jose Luis
Benlloch, María
Franco-Martinez, Lorena
Tvarijonaviciute, Asta
Escribá-Alepuz, Jesús
Sancho-Castillo, Sandra
author_sort de la Rubia Ortí, Jose Enrique
collection PubMed
description Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. After 4 months of intervention with 27 MS patients, we observed that Hp does not significantly increase, alongside a significant decrease in IL-6 and a significant increase in muscle percentage. At the same time, Hp synthesis is considerably and positively correlated with IL-6 both before and after treatment; while this correlation occurs significantly reversed with muscle percentage before treatment, no correlation is evident after the intervention. These results seem to indicate that Hp could be a marker of muscle status and could be a diagnosis tool after therapeutic intervention in MS patients.
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spelling pubmed-81430852021-05-25 Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study de la Rubia Ortí, Jose Enrique Platero, Jose Luis Benlloch, María Franco-Martinez, Lorena Tvarijonaviciute, Asta Escribá-Alepuz, Jesús Sancho-Castillo, Sandra Biomolecules Article Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. After 4 months of intervention with 27 MS patients, we observed that Hp does not significantly increase, alongside a significant decrease in IL-6 and a significant increase in muscle percentage. At the same time, Hp synthesis is considerably and positively correlated with IL-6 both before and after treatment; while this correlation occurs significantly reversed with muscle percentage before treatment, no correlation is evident after the intervention. These results seem to indicate that Hp could be a marker of muscle status and could be a diagnosis tool after therapeutic intervention in MS patients. MDPI 2021-04-21 /pmc/articles/PMC8143085/ /pubmed/33919169 http://dx.doi.org/10.3390/biom11050617 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de la Rubia Ortí, Jose Enrique
Platero, Jose Luis
Benlloch, María
Franco-Martinez, Lorena
Tvarijonaviciute, Asta
Escribá-Alepuz, Jesús
Sancho-Castillo, Sandra
Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
title Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
title_full Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
title_fullStr Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
title_full_unstemmed Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
title_short Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
title_sort role of haptoglobin as a marker of muscular improvement in patients with multiple sclerosis after administration of epigallocatechin gallate and increase of beta-hydroxybutyrate in the blood: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143085/
https://www.ncbi.nlm.nih.gov/pubmed/33919169
http://dx.doi.org/10.3390/biom11050617
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