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Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study

Antibiotic resistance has become a serious global health threat. Wastewater treatment plants may become unintentional collection points for bacteria resistant to antimicrobials. Little is known about the transmission of antibiotic resistance from wastewater treatment plants to humans, most important...

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Autores principales: Wengenroth, Laura, Berglund, Fanny, Blaak, Hetty, Chifiriuc, Mariana Carmen, Flach, Carl-Fredrik, Pircalabioru, Gratiela Gradisteanu, Larsson, D. G. Joakim, Marutescu, Luminita, van Passel, Mark W. J., Popa, Marcela, Radon, Katja, de Roda Husman, Ana Maria, Rodríguez-Molina, Daloha, Weinmann, Tobias, Wieser, Andreas, Schmitt, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143112/
https://www.ncbi.nlm.nih.gov/pubmed/33919179
http://dx.doi.org/10.3390/antibiotics10050478
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author Wengenroth, Laura
Berglund, Fanny
Blaak, Hetty
Chifiriuc, Mariana Carmen
Flach, Carl-Fredrik
Pircalabioru, Gratiela Gradisteanu
Larsson, D. G. Joakim
Marutescu, Luminita
van Passel, Mark W. J.
Popa, Marcela
Radon, Katja
de Roda Husman, Ana Maria
Rodríguez-Molina, Daloha
Weinmann, Tobias
Wieser, Andreas
Schmitt, Heike
author_facet Wengenroth, Laura
Berglund, Fanny
Blaak, Hetty
Chifiriuc, Mariana Carmen
Flach, Carl-Fredrik
Pircalabioru, Gratiela Gradisteanu
Larsson, D. G. Joakim
Marutescu, Luminita
van Passel, Mark W. J.
Popa, Marcela
Radon, Katja
de Roda Husman, Ana Maria
Rodríguez-Molina, Daloha
Weinmann, Tobias
Wieser, Andreas
Schmitt, Heike
author_sort Wengenroth, Laura
collection PubMed
description Antibiotic resistance has become a serious global health threat. Wastewater treatment plants may become unintentional collection points for bacteria resistant to antimicrobials. Little is known about the transmission of antibiotic resistance from wastewater treatment plants to humans, most importantly to wastewater treatment plant workers and residents living in the vicinity. We aim to deliver precise information about the methods used in the AWARE (Antibiotic Resistance in Wastewater: Transmission Risks for Employees and Residents around Wastewater Treatment Plants) study. Within the AWARE study, we gathered data on the prevalence of two antibiotic resistance phenotypes, ESBL-producing E. coli and carbapenemase-producing Enterobacteriaceae, as well as on their corresponding antibiotic resistance genes isolated from air, water, and sewage samples taken from inside and outside of different wastewater treatment plants in Germany, the Netherlands, and Romania. Additionally, we analysed stool samples of wastewater treatment plant workers, nearby residents, and members of a comparison group living ≥1000 m away from the closest WWTP. To our knowledge, this is the first study investigating the potential spread of ESBL-producing E. coli, carbapenemase-producing Enterobacteriaceae, and antibiotic resistance genes from WWTPs to workers, the environment, and nearby residents. Quantifying the contribution of different wastewater treatment processes to the removal efficiency of ESBL-producing E. coli, carbapenemase-producing Enterobacteriaceae, and antibiotic resistance genes will provide us with evidence-based support for possible mitigation strategies.
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spelling pubmed-81431122021-05-25 Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study Wengenroth, Laura Berglund, Fanny Blaak, Hetty Chifiriuc, Mariana Carmen Flach, Carl-Fredrik Pircalabioru, Gratiela Gradisteanu Larsson, D. G. Joakim Marutescu, Luminita van Passel, Mark W. J. Popa, Marcela Radon, Katja de Roda Husman, Ana Maria Rodríguez-Molina, Daloha Weinmann, Tobias Wieser, Andreas Schmitt, Heike Antibiotics (Basel) Study Protocol Antibiotic resistance has become a serious global health threat. Wastewater treatment plants may become unintentional collection points for bacteria resistant to antimicrobials. Little is known about the transmission of antibiotic resistance from wastewater treatment plants to humans, most importantly to wastewater treatment plant workers and residents living in the vicinity. We aim to deliver precise information about the methods used in the AWARE (Antibiotic Resistance in Wastewater: Transmission Risks for Employees and Residents around Wastewater Treatment Plants) study. Within the AWARE study, we gathered data on the prevalence of two antibiotic resistance phenotypes, ESBL-producing E. coli and carbapenemase-producing Enterobacteriaceae, as well as on their corresponding antibiotic resistance genes isolated from air, water, and sewage samples taken from inside and outside of different wastewater treatment plants in Germany, the Netherlands, and Romania. Additionally, we analysed stool samples of wastewater treatment plant workers, nearby residents, and members of a comparison group living ≥1000 m away from the closest WWTP. To our knowledge, this is the first study investigating the potential spread of ESBL-producing E. coli, carbapenemase-producing Enterobacteriaceae, and antibiotic resistance genes from WWTPs to workers, the environment, and nearby residents. Quantifying the contribution of different wastewater treatment processes to the removal efficiency of ESBL-producing E. coli, carbapenemase-producing Enterobacteriaceae, and antibiotic resistance genes will provide us with evidence-based support for possible mitigation strategies. MDPI 2021-04-21 /pmc/articles/PMC8143112/ /pubmed/33919179 http://dx.doi.org/10.3390/antibiotics10050478 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
Wengenroth, Laura
Berglund, Fanny
Blaak, Hetty
Chifiriuc, Mariana Carmen
Flach, Carl-Fredrik
Pircalabioru, Gratiela Gradisteanu
Larsson, D. G. Joakim
Marutescu, Luminita
van Passel, Mark W. J.
Popa, Marcela
Radon, Katja
de Roda Husman, Ana Maria
Rodríguez-Molina, Daloha
Weinmann, Tobias
Wieser, Andreas
Schmitt, Heike
Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
title Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
title_full Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
title_fullStr Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
title_full_unstemmed Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
title_short Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
title_sort antibiotic resistance in wastewater treatment plants and transmission risks for employees and residents: the concept of the aware study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143112/
https://www.ncbi.nlm.nih.gov/pubmed/33919179
http://dx.doi.org/10.3390/antibiotics10050478
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