Cargando…

Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons

Tau aggregation within neurons is a critical feature of Alzheimer's disease (AD) and related tauopathies. It is believed that soluble pathologic tau species seed the formation of tau aggregates in a prion-like manner and propagate through connected neurons during the progression of disease. Bot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oakley, Derek H., Klickstein, Naomi, Commins, Caitlin, Chung, Mirra, Dujardin, Simon, Bennett, Rachel E., Hyman, Bradley T., Frosch, Matthew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143197/ https://www.ncbi.nlm.nih.gov/pubmed/33893219 http://dx.doi.org/10.1523/JNEUROSCI.2590-20.2021

Ejemplares similares

Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases
por: Kamath, Tarun V, et al.
Publicado: (2021)

Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
por: Perez-Rando, Marta, et al.
Publicado: (2020)

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
por: DeVos, Sarah L., et al.
Publicado: (2018)

Using Human iPSC-Derived Neurons to Model TAU Aggregation
por: Verheyen, An, et al.
Publicado: (2015)

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
por: Samelson, Avi J., et al.
Publicado: (2023)

Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
por: Manos, Justine D., et al.
Publicado: (2021)

Tau propagation is dependent on the genetic background of mouse strains
por: Dujardin, Simon, et al.
Publicado: (2022)

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability
por: Silva, M. Catarina, et al.
Publicado: (2016)

Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons
por: Schinke, Christian, et al.
Publicado: (2021)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening
por: Wang, Chao, et al.
Publicado: (2017)

Isolation of Human CD49f(+) Astrocytes and In Vitro iPSC-Based Neurotoxicity Assays
por: Barbar, Lilianne, et al.
Publicado: (2020)

Identifying the dynamics of actin and tubulin polymerization in iPSCs and in iPSC-derived neurons
por: Magliocca, Valentina, et al.
Publicado: (2017)

Molecular and functional variation in iPSC-derived sensory neurons
por: Schwartzentruber, Jeremy, et al.
Publicado: (2017)

Transcriptome Dynamics of Human Neuronal Differentiation From iPSC
por: Kuruş, Meltem, et al.
Publicado: (2021)

Tau protein liquid–liquid phase separation can initiate tau aggregation
por: Wegmann, Susanne, et al.
Publicado: (2018)

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
por: Zhong, Xiali, et al.
Publicado: (2020)

Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells
por: Lathuiliere, Aurelien, et al.
Publicado: (2023)

High-content analysis of neuronal morphology in human iPSC-derived neurons
por: Lickfett, Selene, et al.
Publicado: (2022)

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
por: Mate De Gerando, Anastasie, et al.
Publicado: (2023)

Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing
por: Cervetto, Chiara, et al.
Publicado: (2023)

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
por: van der Kant, Rik, et al.
Publicado: (2019)

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
por: Varderidou-Minasian, Suzy, et al.
Publicado: (2020)

Preparation and Co‐Culture of iPSC‐Derived Dopaminergic Neurons and Astrocytes
por: de Rus Jacquet, Aurelie
Publicado: (2019)

Human iPSC-Derived Cortical Neurons Display Homeostatic Plasticity
por: Cordella, Federica, et al.
Publicado: (2022)

Automated high-content imaging in iPSC-derived neuronal progenitors
por: Papandreou, Apostolos, et al.
Publicado: (2023)

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain
por: Takeda, Shuko, et al.
Publicado: (2015)

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses
por: Podvin, Sonia, et al.
Publicado: (2020)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

Neural cortical organoids from self-assembling human iPSC as a model to investigate neurotoxicity in brain ischemia
por: De Paola, Massimiliano, et al.
Publicado: (2023)

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
por: Imamura, Keiko, et al.
Publicado: (2016)

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
por: Robbins, Jacqueline P., et al.
Publicado: (2018)

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022)

Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings
por: Girardin, Sophie, et al.
Publicado: (2022)

Engineering circuits of human iPSC-derived neurons and rat primary glia
por: Girardin, Sophie, et al.
Publicado: (2023)

Cytokine Profiling in Human iPSC-Derived Dopaminergic Neuronal and Microglial Cultures
por: Knappe, Evelyn, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3o3cn6ndcrf2l8k03ugej84ou1