Role of laminin and cognate receptors in cholangiocarcinoma cell migration

Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin...

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Autores principales: Islam, Kittiya, Thummarati, Parichut, Kaewkong, Pakkanun, Sripa, Banchob, Suthiphongchai, Tuangporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143218/
https://www.ncbi.nlm.nih.gov/pubmed/34014802
http://dx.doi.org/10.1080/19336918.2021.1924422
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author Islam, Kittiya
Thummarati, Parichut
Kaewkong, Pakkanun
Sripa, Banchob
Suthiphongchai, Tuangporn
author_facet Islam, Kittiya
Thummarati, Parichut
Kaewkong, Pakkanun
Sripa, Banchob
Suthiphongchai, Tuangporn
author_sort Islam, Kittiya
collection PubMed
description Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated with lymphatic invasion and the presence of ITGB4 was also associated with short survival time. ITGB4 silencing revealed it as the receptor for laminin-induced HuCCA-1 migration, but KKU-213 utilized 37/67-kDa laminin receptor (LAMR) instead. These findings highlight the role of ITGB4 and LAMR in transducing laminin induction of CCA cell migration and the potential of ITGB4 as diagnostic and prognostic biomarkers for CCA.
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spelling pubmed-81432182021-06-07 Role of laminin and cognate receptors in cholangiocarcinoma cell migration Islam, Kittiya Thummarati, Parichut Kaewkong, Pakkanun Sripa, Banchob Suthiphongchai, Tuangporn Cell Adh Migr Research Paper Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated with lymphatic invasion and the presence of ITGB4 was also associated with short survival time. ITGB4 silencing revealed it as the receptor for laminin-induced HuCCA-1 migration, but KKU-213 utilized 37/67-kDa laminin receptor (LAMR) instead. These findings highlight the role of ITGB4 and LAMR in transducing laminin induction of CCA cell migration and the potential of ITGB4 as diagnostic and prognostic biomarkers for CCA. Taylor & Francis 2021-05-20 /pmc/articles/PMC8143218/ /pubmed/34014802 http://dx.doi.org/10.1080/19336918.2021.1924422 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Islam, Kittiya
Thummarati, Parichut
Kaewkong, Pakkanun
Sripa, Banchob
Suthiphongchai, Tuangporn
Role of laminin and cognate receptors in cholangiocarcinoma cell migration
title Role of laminin and cognate receptors in cholangiocarcinoma cell migration
title_full Role of laminin and cognate receptors in cholangiocarcinoma cell migration
title_fullStr Role of laminin and cognate receptors in cholangiocarcinoma cell migration
title_full_unstemmed Role of laminin and cognate receptors in cholangiocarcinoma cell migration
title_short Role of laminin and cognate receptors in cholangiocarcinoma cell migration
title_sort role of laminin and cognate receptors in cholangiocarcinoma cell migration
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143218/
https://www.ncbi.nlm.nih.gov/pubmed/34014802
http://dx.doi.org/10.1080/19336918.2021.1924422
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