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A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143327/ https://www.ncbi.nlm.nih.gov/pubmed/33919314 http://dx.doi.org/10.3390/v13050724 |
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author | Resende, Paola Cristina Gräf, Tiago Paixão, Anna Carolina Dias Appolinario, Luciana Lopes, Renata Serrano Mendonça, Ana Carolina da Fonseca da Rocha, Alice Sampaio Barreto Motta, Fernando Couto Neto, Lidio Gonçalves Lima Khouri, Ricardo de Oliveira, Camila I. Santos-Muccillo, Pedro Bezerra, João Felipe Teixeira, Dalane Loudal Florentino Riediger, Irina Debur, Maria do Carmo Ribeiro-Rodrigues, Rodrigo Leite, Anderson Brandao do Santos, Cliomar Alves Gregianini, Tatiana Schäffer Fernandes, Sandra Bianchini Bernardes, André Felipe Leal Cavalcanti, Andrea Cony Miyajima, Fábio Sachhi, Claudio Mattos, Tirza da Costa, Cristiano Fernandes Delatorre, Edson Wallau, Gabriel L. Naveca, Felipe G. Bello, Gonzalo Siqueira, Marilda Mendonça |
author_facet | Resende, Paola Cristina Gräf, Tiago Paixão, Anna Carolina Dias Appolinario, Luciana Lopes, Renata Serrano Mendonça, Ana Carolina da Fonseca da Rocha, Alice Sampaio Barreto Motta, Fernando Couto Neto, Lidio Gonçalves Lima Khouri, Ricardo de Oliveira, Camila I. Santos-Muccillo, Pedro Bezerra, João Felipe Teixeira, Dalane Loudal Florentino Riediger, Irina Debur, Maria do Carmo Ribeiro-Rodrigues, Rodrigo Leite, Anderson Brandao do Santos, Cliomar Alves Gregianini, Tatiana Schäffer Fernandes, Sandra Bianchini Bernardes, André Felipe Leal Cavalcanti, Andrea Cony Miyajima, Fábio Sachhi, Claudio Mattos, Tirza da Costa, Cristiano Fernandes Delatorre, Edson Wallau, Gabriel L. Naveca, Felipe G. Bello, Gonzalo Siqueira, Marilda Mendonça |
author_sort | Resende, Paola Cristina |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions. |
format | Online Article Text |
id | pubmed-8143327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81433272021-05-25 A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil Resende, Paola Cristina Gräf, Tiago Paixão, Anna Carolina Dias Appolinario, Luciana Lopes, Renata Serrano Mendonça, Ana Carolina da Fonseca da Rocha, Alice Sampaio Barreto Motta, Fernando Couto Neto, Lidio Gonçalves Lima Khouri, Ricardo de Oliveira, Camila I. Santos-Muccillo, Pedro Bezerra, João Felipe Teixeira, Dalane Loudal Florentino Riediger, Irina Debur, Maria do Carmo Ribeiro-Rodrigues, Rodrigo Leite, Anderson Brandao do Santos, Cliomar Alves Gregianini, Tatiana Schäffer Fernandes, Sandra Bianchini Bernardes, André Felipe Leal Cavalcanti, Andrea Cony Miyajima, Fábio Sachhi, Claudio Mattos, Tirza da Costa, Cristiano Fernandes Delatorre, Edson Wallau, Gabriel L. Naveca, Felipe G. Bello, Gonzalo Siqueira, Marilda Mendonça Viruses Communication The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions. MDPI 2021-04-21 /pmc/articles/PMC8143327/ /pubmed/33919314 http://dx.doi.org/10.3390/v13050724 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Resende, Paola Cristina Gräf, Tiago Paixão, Anna Carolina Dias Appolinario, Luciana Lopes, Renata Serrano Mendonça, Ana Carolina da Fonseca da Rocha, Alice Sampaio Barreto Motta, Fernando Couto Neto, Lidio Gonçalves Lima Khouri, Ricardo de Oliveira, Camila I. Santos-Muccillo, Pedro Bezerra, João Felipe Teixeira, Dalane Loudal Florentino Riediger, Irina Debur, Maria do Carmo Ribeiro-Rodrigues, Rodrigo Leite, Anderson Brandao do Santos, Cliomar Alves Gregianini, Tatiana Schäffer Fernandes, Sandra Bianchini Bernardes, André Felipe Leal Cavalcanti, Andrea Cony Miyajima, Fábio Sachhi, Claudio Mattos, Tirza da Costa, Cristiano Fernandes Delatorre, Edson Wallau, Gabriel L. Naveca, Felipe G. Bello, Gonzalo Siqueira, Marilda Mendonça A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil |
title | A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil |
title_full | A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil |
title_fullStr | A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil |
title_full_unstemmed | A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil |
title_short | A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil |
title_sort | potential sars-cov-2 variant of interest (voi) harboring mutation e484k in the spike protein was identified within lineage b.1.1.33 circulating in brazil |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143327/ https://www.ncbi.nlm.nih.gov/pubmed/33919314 http://dx.doi.org/10.3390/v13050724 |
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