Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug

IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species. Four metabolites of IMMH-010 were identified, and the major metabolite was the parent compound, YPD-29B, which was mainly c...

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Detalles Bibliográficos
Autores principales: Wang, Yuchen, Liu, Xiao, Zou, Xiaowen, Wang, Shuting, Luo, Lijun, Liu, Yuke, Dong, Kai, Yao, Xiaoqing, Li, Yan, Chen, Xiaoguang, Sheng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143347/
https://www.ncbi.nlm.nih.gov/pubmed/33919384
http://dx.doi.org/10.3390/pharmaceutics13050598

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