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SARS-CoV-2 and Placenta: New Insights and Perspectives
The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechani...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143362/ https://www.ncbi.nlm.nih.gov/pubmed/33919284 http://dx.doi.org/10.3390/v13050723 |
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author | Resta, Leonardo Vimercati, Antonella Cazzato, Gerardo Mazzia, Giulia Cicinelli, Ettore Colagrande, Anna Fanelli, Margherita Scarcella, Sara Vincenza Ceci, Oronzo Rossi, Roberta |
author_facet | Resta, Leonardo Vimercati, Antonella Cazzato, Gerardo Mazzia, Giulia Cicinelli, Ettore Colagrande, Anna Fanelli, Margherita Scarcella, Sara Vincenza Ceci, Oronzo Rossi, Roberta |
author_sort | Resta, Leonardo |
collection | PubMed |
description | The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. A case–control study was conducted in order to highlight any histopathological alterations attributable to SARS-CoV-2. The prevalence of maternal vascular malperfusion was not significantly different between cases and controls (54.3% vs. 43.7% p = 0.19), whereas the differences with regard to fetal vascular malperfusion (21.1% vs. 4.2% p < 0.001) were significant. More frequent in cases with respect to controls were decidual arteriopathy (40.9% vs. 1.4% p < 0.0001), decidual inflammation (32.4% vs. 0.7% p < 0.0001), perivillous fibrin deposition (36.6% vs. 3.5% p < 0.0001) and fetal vessel thrombi (22.5% vs. 0.7% p < 0.0001). No significant differences in the percentage of terminal villous hyperplasia and chorioamnionitis were observed between the two groups. As the pandemic continues, these studies will become more urgent in order to clarify the possible mechanism of maternal–fetal transmission of the virus. |
format | Online Article Text |
id | pubmed-8143362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81433622021-05-25 SARS-CoV-2 and Placenta: New Insights and Perspectives Resta, Leonardo Vimercati, Antonella Cazzato, Gerardo Mazzia, Giulia Cicinelli, Ettore Colagrande, Anna Fanelli, Margherita Scarcella, Sara Vincenza Ceci, Oronzo Rossi, Roberta Viruses Article The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. A case–control study was conducted in order to highlight any histopathological alterations attributable to SARS-CoV-2. The prevalence of maternal vascular malperfusion was not significantly different between cases and controls (54.3% vs. 43.7% p = 0.19), whereas the differences with regard to fetal vascular malperfusion (21.1% vs. 4.2% p < 0.001) were significant. More frequent in cases with respect to controls were decidual arteriopathy (40.9% vs. 1.4% p < 0.0001), decidual inflammation (32.4% vs. 0.7% p < 0.0001), perivillous fibrin deposition (36.6% vs. 3.5% p < 0.0001) and fetal vessel thrombi (22.5% vs. 0.7% p < 0.0001). No significant differences in the percentage of terminal villous hyperplasia and chorioamnionitis were observed between the two groups. As the pandemic continues, these studies will become more urgent in order to clarify the possible mechanism of maternal–fetal transmission of the virus. MDPI 2021-04-21 /pmc/articles/PMC8143362/ /pubmed/33919284 http://dx.doi.org/10.3390/v13050723 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Resta, Leonardo Vimercati, Antonella Cazzato, Gerardo Mazzia, Giulia Cicinelli, Ettore Colagrande, Anna Fanelli, Margherita Scarcella, Sara Vincenza Ceci, Oronzo Rossi, Roberta SARS-CoV-2 and Placenta: New Insights and Perspectives |
title | SARS-CoV-2 and Placenta: New Insights and Perspectives |
title_full | SARS-CoV-2 and Placenta: New Insights and Perspectives |
title_fullStr | SARS-CoV-2 and Placenta: New Insights and Perspectives |
title_full_unstemmed | SARS-CoV-2 and Placenta: New Insights and Perspectives |
title_short | SARS-CoV-2 and Placenta: New Insights and Perspectives |
title_sort | sars-cov-2 and placenta: new insights and perspectives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143362/ https://www.ncbi.nlm.nih.gov/pubmed/33919284 http://dx.doi.org/10.3390/v13050723 |
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