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SARS-CoV-2 and Placenta: New Insights and Perspectives

The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechani...

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Autores principales: Resta, Leonardo, Vimercati, Antonella, Cazzato, Gerardo, Mazzia, Giulia, Cicinelli, Ettore, Colagrande, Anna, Fanelli, Margherita, Scarcella, Sara Vincenza, Ceci, Oronzo, Rossi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143362/
https://www.ncbi.nlm.nih.gov/pubmed/33919284
http://dx.doi.org/10.3390/v13050723
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author Resta, Leonardo
Vimercati, Antonella
Cazzato, Gerardo
Mazzia, Giulia
Cicinelli, Ettore
Colagrande, Anna
Fanelli, Margherita
Scarcella, Sara Vincenza
Ceci, Oronzo
Rossi, Roberta
author_facet Resta, Leonardo
Vimercati, Antonella
Cazzato, Gerardo
Mazzia, Giulia
Cicinelli, Ettore
Colagrande, Anna
Fanelli, Margherita
Scarcella, Sara Vincenza
Ceci, Oronzo
Rossi, Roberta
author_sort Resta, Leonardo
collection PubMed
description The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. A case–control study was conducted in order to highlight any histopathological alterations attributable to SARS-CoV-2. The prevalence of maternal vascular malperfusion was not significantly different between cases and controls (54.3% vs. 43.7% p = 0.19), whereas the differences with regard to fetal vascular malperfusion (21.1% vs. 4.2% p < 0.001) were significant. More frequent in cases with respect to controls were decidual arteriopathy (40.9% vs. 1.4% p < 0.0001), decidual inflammation (32.4% vs. 0.7% p < 0.0001), perivillous fibrin deposition (36.6% vs. 3.5% p < 0.0001) and fetal vessel thrombi (22.5% vs. 0.7% p < 0.0001). No significant differences in the percentage of terminal villous hyperplasia and chorioamnionitis were observed between the two groups. As the pandemic continues, these studies will become more urgent in order to clarify the possible mechanism of maternal–fetal transmission of the virus.
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spelling pubmed-81433622021-05-25 SARS-CoV-2 and Placenta: New Insights and Perspectives Resta, Leonardo Vimercati, Antonella Cazzato, Gerardo Mazzia, Giulia Cicinelli, Ettore Colagrande, Anna Fanelli, Margherita Scarcella, Sara Vincenza Ceci, Oronzo Rossi, Roberta Viruses Article The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. A case–control study was conducted in order to highlight any histopathological alterations attributable to SARS-CoV-2. The prevalence of maternal vascular malperfusion was not significantly different between cases and controls (54.3% vs. 43.7% p = 0.19), whereas the differences with regard to fetal vascular malperfusion (21.1% vs. 4.2% p < 0.001) were significant. More frequent in cases with respect to controls were decidual arteriopathy (40.9% vs. 1.4% p < 0.0001), decidual inflammation (32.4% vs. 0.7% p < 0.0001), perivillous fibrin deposition (36.6% vs. 3.5% p < 0.0001) and fetal vessel thrombi (22.5% vs. 0.7% p < 0.0001). No significant differences in the percentage of terminal villous hyperplasia and chorioamnionitis were observed between the two groups. As the pandemic continues, these studies will become more urgent in order to clarify the possible mechanism of maternal–fetal transmission of the virus. MDPI 2021-04-21 /pmc/articles/PMC8143362/ /pubmed/33919284 http://dx.doi.org/10.3390/v13050723 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Resta, Leonardo
Vimercati, Antonella
Cazzato, Gerardo
Mazzia, Giulia
Cicinelli, Ettore
Colagrande, Anna
Fanelli, Margherita
Scarcella, Sara Vincenza
Ceci, Oronzo
Rossi, Roberta
SARS-CoV-2 and Placenta: New Insights and Perspectives
title SARS-CoV-2 and Placenta: New Insights and Perspectives
title_full SARS-CoV-2 and Placenta: New Insights and Perspectives
title_fullStr SARS-CoV-2 and Placenta: New Insights and Perspectives
title_full_unstemmed SARS-CoV-2 and Placenta: New Insights and Perspectives
title_short SARS-CoV-2 and Placenta: New Insights and Perspectives
title_sort sars-cov-2 and placenta: new insights and perspectives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143362/
https://www.ncbi.nlm.nih.gov/pubmed/33919284
http://dx.doi.org/10.3390/v13050723
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