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Patterns of selection against centrosome amplification in human cell lines
The presence of extra centrioles, termed centrosome amplification, is a hallmark of cancer. The distribution of centriole numbers within a cancer cell population appears to be at an equilibrium maintained by centriole overproduction and selection, reminiscent of mutation-selection balance. It is unk...
Autores principales: | Dias Louro, Marco António, Bettencourt-Dias, Mónica, Bank, Claudia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143425/ https://www.ncbi.nlm.nih.gov/pubmed/33979341 http://dx.doi.org/10.1371/journal.pcbi.1008765 |
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